Enantioselective Mukaiyama-Michael Reaction of Cyclic α-Alkylidene β-Keto Phosphine Oxide and Phosphonate and Asymmetric Synthesis of (R)-Homosarkomycin

Kotaro Nagatani; Atsushi Minami; Haruka Tezuka; Yunosuke Hoshino; Masahisa Nakada

doi:10.1021/acs.orglett.6b03798

Enantioselective Mukaiyama-Michael Reaction of Cyclic α-Alkylidene β-Keto Phosphine Oxide and Phosphonate and Asymmetric Synthesis of (R)-Homosarkomycin

Kotaro Nagatani, Atsushi Minami, Haruka Tezuka, Yunosuke Hoshino, Masahisa Nakada^*

^*この研究の対応する著者

研究成果: Article › 査読

22 被引用数 (Scopus)

抄録

The asymmetric Mukaiyama-Michael reaction of cyclic α-alkylidene β-oxo phosphates and phosphine oxides that proceeds in a highly enantioselective manner is described. It is possible to carry out these reactions using a catalytic amount of a bisoxazoline-Cu(II) complex without decreasing the enantioselectivity, and one of the products has been successfully used for the first enantioselective synthesis of (R)-homosarkomycin.

本文言語	English
ページ（範囲）	810-813
ページ数	4
ジャーナル	Organic Letters
巻	19
号	4
DOI	https://doi.org/10.1021/acs.orglett.6b03798
出版ステータス	Published - 2017 2月 17

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

文献へのアクセス

10.1021/acs.orglett.6b03798

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引用スタイル

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AU - Tezuka, Haruka

AU - Hoshino, Yunosuke

AU - Nakada, Masahisa

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