抄録
In this paper, the first total synthesis of (+)-bucidarasins A and C is described. The chiral starting material was successfully obtained via reduction using a CBS catalyst and selective mono-TBS ether formation of trans -2-benzyloxymethyl-2-methylcyclohexane-1,3-diol, which was crucial to the successful enantioselective total synthesis of (+)-bucidarasins A and C. A synthetic approach towards (+)-bucidarasin C, based on the Barton-McCombie protocol, using V-70 as a radical promoter at low temperature to remove the C6-hydroxy moiety is also described.
本文言語 | English |
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ページ(範囲) | 332-350 |
ページ数 | 19 |
ジャーナル | Heterocycles |
巻 | 91 |
号 | 2 |
DOI | |
出版ステータス | Published - 2015 |
ASJC Scopus subject areas
- 分析化学
- 薬理学
- 有機化学