抄録
Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.
本文言語 | English |
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ページ(範囲) | 305-312 |
ページ数 | 8 |
ジャーナル | ACS Nano |
巻 | 13 |
号 | 1 |
DOI | |
出版ステータス | Published - 2019 1月 22 |
ASJC Scopus subject areas
- 材料科学一般
- 工学一般
- 物理学および天文学一般