Enhancement by prolactin of the GnRH-induced release of LH from dispersed anterior pituitary cells of the bullfrog (Rana catesbeiana)

A. Oguchi, S. Tanaka, T. Aida, K. Yamamoto, S. Kikuyama*

*この研究の対応する著者

    研究成果: Article査読

    16 被引用数 (Scopus)

    抄録

    The response of enzymatically dispersed anterior pituitary cells of the bullfrog (Rana catesbeiana) to gonadotropin-releasing hormone (GnRH) was studied by monitoring the release of luteinizing hormone (LH) into the culture medium. The cells responded to GnRH by releasing LH according to the incubation time and to the GnRH concentration. The responsiveness to GnRH became less conspicuous as the cell density was reduced. Addition of prolactin (PRL) to the medium enhanced the responsiveness to the secretagogue, and addition of antiserum against PRL lowered the responsiveness to a certain extent. Immunohistochemical studies of sectioned pituitaries revealed that PRL cells most frequently located in contact with LH cells. The possibility that PRL acts directly on gonadotrophs to enhance their responsiveness to GnRH was suggested.

    本文言語English
    ページ(範囲)128-135
    ページ数8
    ジャーナルGeneral and Comparative Endocrinology
    107
    1
    DOI
    出版ステータスPublished - 1997 7月

    ASJC Scopus subject areas

    • 内分泌学

    フィンガープリント

    「Enhancement by prolactin of the GnRH-induced release of LH from dispersed anterior pituitary cells of the bullfrog (Rana catesbeiana)」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル