Enterotypes in the landscape of gut microbial community composition

Paul I. Costea; Falk Hildebrand; Arumugam Manimozhiyan; Fredrik Bäckhed; Martin J. Blaser; Frederic D. Bushman; Willem M. De Vos; S. Dusko Ehrlich; Claire M. Fraser; Masahira Hattori; Curtis Huttenhower; Ian B. Jeffery; Dan Knights; James D. Lewis; Ruth E. Ley; Howard Ochman; Paul W. O'Toole; Christopher Quince; David A. Relman; Fergus Shanahan; Shinichi Sunagawa; Jun Wang; George M. Weinstock; Gary D. Wu; Georg Zeller; Liping Zhao; Jeroen Raes; Rob Knight; Peer Bork

doi:10.1038/s41564-017-0072-8

Enterotypes in the landscape of gut microbial community composition

Paul I. Costea, Falk Hildebrand, Arumugam Manimozhiyan, Fredrik Bäckhed, Martin J. Blaser, Frederic D. Bushman, Willem M. De Vos, S. Dusko Ehrlich, Claire M. Fraser, Masahira Hattori, Curtis Huttenhower, Ian B. Jeffery, Dan Knights, James D. Lewis, Ruth E. Ley, Howard Ochman, Paul W. O'Toole, Christopher Quince, David A. Relman, Fergus ShanahanShinichi Sunagawa, Jun Wang, George M. Weinstock, Gary D. Wu, Georg Zeller, Liping Zhao, Jeroen Raes^*, Rob Knight, Peer Bork

^*この研究の対応する著者

研究成果: Article › 査読

485 被引用数 (Scopus)

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Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept.

本文言語	English
ページ（範囲）	8-16
ページ数	9
ジャーナル	Nature Microbiology
巻	3
号	1
DOI	https://doi.org/10.1038/s41564-017-0072-8
出版ステータス	Published - 2017 1月 1

ASJC Scopus subject areas

微生物学
免疫学
応用微生物学とバイオテクノロジー
遺伝学
微生物学（医療）
細胞生物学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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Costea, P. I., Hildebrand, F., Manimozhiyan, A., Bäckhed, F., Blaser, M. J., Bushman, F. D., De Vos, W. M., Ehrlich, S. D., Fraser, C. M., Hattori, M., Huttenhower, C., Jeffery, I. B., Knights, D., Lewis, J. D., Ley, R. E., Ochman, H., O'Toole, P. W., Quince, C., Relman, D. A., ... Bork, P. (2017). Enterotypes in the landscape of gut microbial community composition. Nature Microbiology, 3(1), 8-16. https://doi.org/10.1038/s41564-017-0072-8

Costea, PI, Hildebrand, F, Manimozhiyan, A, Bäckhed, F, Blaser, MJ, Bushman, FD, De Vos, WM, Ehrlich, SD, Fraser, CM, Hattori, M, Huttenhower, C, Jeffery, IB, Knights, D, Lewis, JD, Ley, RE, Ochman, H, O'Toole, PW, Quince, C, Relman, DA, Shanahan, F, Sunagawa, S, Wang, J, Weinstock, GM, Wu, GD, Zeller, G, Zhao, L, Raes, J, Knight, R & Bork, P 2017, 'Enterotypes in the landscape of gut microbial community composition', Nature Microbiology, vol. 3, no. 1, pp. 8-16. https://doi.org/10.1038/s41564-017-0072-8

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AU - De Vos, Willem M.

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AU - Fraser, Claire M.

AU - Hattori, Masahira

AU - Huttenhower, Curtis

AU - Jeffery, Ian B.

AU - Knights, Dan

AU - Lewis, James D.

AU - Ley, Ruth E.

AU - Ochman, Howard

AU - O'Toole, Paul W.

AU - Quince, Christopher

AU - Relman, David A.

AU - Shanahan, Fergus

AU - Sunagawa, Shinichi

AU - Wang, Jun

AU - Weinstock, George M.

AU - Wu, Gary D.

AU - Zeller, Georg

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AU - Knight, Rob

AU - Bork, Peer

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Enterotypes in the landscape of gut microbial community composition

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ASJC Scopus subject areas

UN SDG

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