Environmental estrogens and reproductive biology in amphibians

G. Mosconi*, O. Carnevali, M. F. Franzoni, E. Cottone, I. Lutz, W. Kloas, K. Yamamoto, S. Kikuyama, A. M. Polzonetti-Magni


    研究成果: Article査読

    89 被引用数 (Scopus)


    In this paper, the effects of an estrogenic compound, 4-nonyl-phenol (NP), on the amphibians Rana esculenta and Triturus carnifex are described together with those on sexual differentiation in Xenopus laevis. NP increased plasma vitellogenin in male frogs and newts in a dose-related manner; moreover, inhibitory effects on gonadotropin and prolactin (PRL) secretion by pituitary were found together with an elevation of plasma androgens. NP treatment also caused a remarkable increase in number of prolactin-immunolabeled cells, suggesting that xenoestrogen might induce, at least in the newt pituitary, a PRL accumulation possibly due to a reduction of the hormone release. In addition, both NP and bisphenol A caused feminization by increasing the percentage of female phenotypes in X. laevis, and the in vivo effects were more pronounced than those of estradiol-17β.

    ジャーナルGeneral and Comparative Endocrinology
    出版ステータスPublished - 2002

    ASJC Scopus subject areas

    • 内分泌学


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