@article{4f2ac866b22a40fb943b2b866e9bdd53,
title = "Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells",
abstract = "Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells was carried out. Azumamide E (5) strongly inhibited in vitro angiogenesis from iPS cells at 1.9 μM while azumamide A (1) showed only weak inhibition at 19 μM. These results were well correlated with HDAC inhibitory activity of these compounds, revealing the prospect of azumamides as the probe molecules useful for stem cell chemical biology.",
keywords = "Angiogenesis, Chemical biology, Histone deacetylase, iPS cells",
author = "Yoichi Nakao and Genta Narazaki and Takuhiro Hoshino and Satoko Maeda and Minoru Yoshida and Hiroshi Maejima and Yamashita, {Jun K.}",
note = "Funding Information: This work was partly supported by the Waseda University Grant for Special Research Projects, the Nissui Research foundation, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. ",
year = "2008",
month = may,
day = "1",
doi = "10.1016/j.bmcl.2008.03.053",
language = "English",
volume = "18",
pages = "2982--2984",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd",
number = "9",
}