Evolutionary conservation and conversion of Foxg1 function in brain development

Takuma Kumamoto, Carina Hanashima*


研究成果: Review article査読

50 被引用数 (Scopus)


Among the forkhead box protein family, Foxg1 is a unique transcription factor that plays pleiotropic and non-redundant roles in vertebrate brain development. The emergence of the telencephalon at the rostral end of the neural tube and its subsequent expansion that is mediated by Foxg1 was a key reason for the vertebrate brain to acquire higher order information processing, where Foxg1 is repetitively used in the sequential events of telencephalic development to control multi-steps of brain circuit formation ranging from cell cycle control to neuronal differentiation in a clade- and species-specific manner. The objective of this review is to discuss how the evolutionary changes in cis- and trans-regulatory network that is mediated by a single transcription factor has contributed to determining the fundamental vertebrate brain structure and its divergent roles in instructing species-specific neuronal circuitry and functional specialization.

ジャーナルDevelopment Growth and Differentiation
出版ステータスPublished - 2017 5月

ASJC Scopus subject areas

  • 発生生物学
  • 細胞生物学


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