TY - JOUR
T1 - Experiment of in vivo imaging with third generation setup using Photon-Counting CT with 64ch Multi-Pixel Photon Counter
AU - Sagisaka, M.
AU - Toyoda, T.
AU - Kataoka, J.
AU - Arimoto, M.
AU - Kawashima, H.
AU - Kobayashi, S.
AU - Murakami, K.
AU - Okumura, K.
AU - Sato, D.
AU - Yoshiura, K.
AU - Mizuno, T.
AU - Aiga, K.
AU - Terazawa, S.
AU - Shiota, S.
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - X-ray computed tomography is one of the commonly used diagnostic imaging technique. However, it has some problems which are lack of energy information and high dose exposure. These problems can be solved by using a next generation CT called Photon Counting CT (PC-CT). PC-CT can acquire multi-color images with significantly low radiation dose. The detector system of the PC-CT we propose consists of Multi-Pixel Photon Counter (MPPC) coupled with a high-speed scintillator thus can be made with lower cost and simpler system. In this study, we propose a novel method of material decomposition using the MPPC based PC-CT. Furthermore, we imaged mice with MPPC based PC-CT system as a first attempt. Iodine and gadolinium mixed contrast agents and gold-nanoparticles (AuNPs) were injected when imaging. In addition, the CT images of mice showed bone, lungs, heart, kidneys, and bladder. As a future prospect, we will work on visualizing the pharmacokinetics in mice.
AB - X-ray computed tomography is one of the commonly used diagnostic imaging technique. However, it has some problems which are lack of energy information and high dose exposure. These problems can be solved by using a next generation CT called Photon Counting CT (PC-CT). PC-CT can acquire multi-color images with significantly low radiation dose. The detector system of the PC-CT we propose consists of Multi-Pixel Photon Counter (MPPC) coupled with a high-speed scintillator thus can be made with lower cost and simpler system. In this study, we propose a novel method of material decomposition using the MPPC based PC-CT. Furthermore, we imaged mice with MPPC based PC-CT system as a first attempt. Iodine and gadolinium mixed contrast agents and gold-nanoparticles (AuNPs) were injected when imaging. In addition, the CT images of mice showed bone, lungs, heart, kidneys, and bladder. As a future prospect, we will work on visualizing the pharmacokinetics in mice.
KW - In-vivo imaging
KW - MPPC
KW - Material decomposition
KW - Photon-Counting CT
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U2 - 10.1016/j.nima.2022.167580
DO - 10.1016/j.nima.2022.167580
M3 - Article
AN - SCOPUS:85142817271
SN - 0168-9002
VL - 1045
JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
M1 - 167580
ER -