TY - JOUR
T1 - Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis
AU - Ueoka, Reiko
AU - Nakao, Yoichi
AU - Kawatsu, Shizuka
AU - Yaegashi, Junko
AU - Matsumoto, Yoshitsugu
AU - Matsunaga, Shigeki
AU - Furihata, Kazuo
AU - Van Soest, Rob W.M.
AU - Fusetani, Nobuhiro
PY - 2009/6/5
Y1 - 2009/6/5
N2 - (Chemical Equation Presented) Three new antiprotozoan compounds, gracilioethers A-C (1-3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A-C showed antimalarial activity against Plasmodium falciparum with IC50 values of 0.5-10 μg/mL, whereas gracilioether B (2) also showed antileishmanial activity.
AB - (Chemical Equation Presented) Three new antiprotozoan compounds, gracilioethers A-C (1-3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A-C showed antimalarial activity against Plasmodium falciparum with IC50 values of 0.5-10 μg/mL, whereas gracilioether B (2) also showed antileishmanial activity.
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U2 - 10.1021/jo900380f
DO - 10.1021/jo900380f
M3 - Article
C2 - 19402618
AN - SCOPUS:66249138875
SN - 0022-3263
VL - 74
SP - 4203
EP - 4207
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 11
ER -
