TY - CONF
T1 - Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes
AU - Okamura, Yosuke
AU - Maekawa, Ippei
AU - Fujie, Toshinori
AU - Takeoka, Shinji
AU - Handa, Makoto
AU - Ikeda, Yasuo
PY - 2005/12/1
Y1 - 2005/12/1
N2 - We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.
AB - We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.
KW - Albumin
KW - Fibrinogen γ chain dodecapeptide (H12)
KW - Haemostatic effect
KW - Platelet substitutes
KW - Thrombocytopenic rats
KW - Vesicles
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M3 - Paper
AN - SCOPUS:33645642239
T2 - 54th SPSJ Annual Meeting 2005
Y2 - 25 May 2005 through 27 May 2005
ER -