Histological and molecular characterization of the femoral attachment of the human ligamentum capitis femoris

Y. Shinohara, T. Kumai*, I. Higashiyama, K. Hayashi, T. Matsuda, Y. Tanaka, Y. Takakura


研究成果: Article査読

10 被引用数 (Scopus)


The ligamentum capitis femoris (LCF) has increased in clinical significance through the development of hip arthroscopy. The histological pathologies and molecular composition of the femoral attachment of the LCF and the degeneration caused by LCF disruption were investigated in the human hip joint. Twenty-four LCFs were retrieved at surgery for femoral neck fracture (age range: 63-87 years). In the "intact" (i.e., intact throughout its length, n=12) group, the attachment consisted of rich fibrocartilage. Fibrocartilage cells were present in the midsubstance. In contrast, the construction of the attachment in the "disrupted" (i.e., ligament no longer attached to the femoral head, n=12) group had disappeared. The attachment in the disrupted group was not labeled for type II collagen or aggrecan, while that in the intact group was labeled for types I, II and III collagen, chondroitin 4-sulfate, chondroitin 6-sulfate, aggrecan, and versican. The percentage of single-stranded DNA-positive chondrocytes was significantly higher in the disrupted group than in the intact group. We conclude that the femoral attachment of the LCF has a characteristic fibrocartilaginous structure that is likely to adjust to the mechanical load, and suggest that its degeneration is advanced by disruption and should be regarded as a clinical pathology.

ジャーナルScandinavian Journal of Medicine and Science in Sports
出版ステータスPublished - 2014 8月

ASJC Scopus subject areas

  • 整形外科およびスポーツ医学
  • 理学療法、スポーツ療法とリハビリテーション


「Histological and molecular characterization of the femoral attachment of the human ligamentum capitis femoris」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。