HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

Kazushi Azuma, Mai Sakamoto, Shota Katayama, Atsuka Matsui, Kazuya Nakamichi, Naoki Goshima, Shinya Watanabe, Jun Nakayama*, Kentaro Semba*

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The homeobox family genes are often dysregulated in various cancer types. Particularly HOXB7 amplification and overexpression correlate with poor prognosis in various cancer such as gastric, pancreatic, and lung cancers. Moreover, HOXB7 is known to contribute to cancer progression by promoting epithelial to mesenchymal transition, anticancer drug resistance, and angiogenesis. In this study, we show that HOXB7 is coamplified with ERBB2 in a subset of breast cancer patients and HOXB7 expression correlates with poor prognosis in HER2-positive breast cancer patients. This clinical observation is supported by the following results—HOXB7 overexpression in an immortalized murine mammary gland epithelial cell line NMuMG induces cellular transformation in vitro, tumorigenesis, and lung metastasis through the activation of JAK-STAT signaling.

本文言語English
ページ(範囲)277-287
ページ数11
ジャーナルGenes to Cells
28
4
DOI
出版ステータスPublished - 2023 4月

ASJC Scopus subject areas

  • 遺伝学
  • 細胞生物学

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