@article{64832e6867b944359a71b7ffb9cfc301,
title = "HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells",
abstract = "The homeobox family genes are often dysregulated in various cancer types. Particularly HOXB7 amplification and overexpression correlate with poor prognosis in various cancer such as gastric, pancreatic, and lung cancers. Moreover, HOXB7 is known to contribute to cancer progression by promoting epithelial to mesenchymal transition, anticancer drug resistance, and angiogenesis. In this study, we show that HOXB7 is coamplified with ERBB2 in a subset of breast cancer patients and HOXB7 expression correlates with poor prognosis in HER2-positive breast cancer patients. This clinical observation is supported by the following results—HOXB7 overexpression in an immortalized murine mammary gland epithelial cell line NMuMG induces cellular transformation in vitro, tumorigenesis, and lung metastasis through the activation of JAK-STAT signaling.",
keywords = "ERBB2, HOXB7, NMuMG, breast cancer, metastasis, oncogene",
author = "Kazushi Azuma and Mai Sakamoto and Shota Katayama and Atsuka Matsui and Kazuya Nakamichi and Naoki Goshima and Shinya Watanabe and Jun Nakayama and Kentaro Semba",
note = "Funding Information: This study was supported by JSPS KAKENHI (grant no. 23241064, Grant‐in‐Aid for Scientific Research (A) to K.S.; grant no. 18K16269: Grant‐in‐Aid for Early‐Career Scientist to J.N.; grant no. 20J01794, Grant in Aid for JSPS fellows to J.N.) and the Japan Biological Informatics Consortium (JBic). Funding Information: We thank Dr. Y. Yamamoto (National Cancer Center Research Institute) and Dr. J. Fujimoto (JBic) for the meaningful comments and discussion, Prof. K. Miyazawa (University of Yamanashi, Yamanashi, Japan) for kindly providing the NMuMG cell line, and Prof. T. Kitamura (Institute of Medical Science, The University of Tokyo, Tokyo, Japan) for kindly providing the Plat-E cell line. This study was conducted in part as a program through the Fukushima Translational Research Project. Publisher Copyright: {\textcopyright} 2023 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.",
year = "2023",
month = apr,
doi = "10.1111/gtc.13009",
language = "English",
volume = "28",
pages = "277--287",
journal = "Genes to Cells",
issn = "1356-9597",
publisher = "Wiley-Blackwell",
number = "4",
}
