@article{1a872a804d934488950724f0baed753e,
title = "Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.",
abstract = "The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 µg/mL.",
keywords = "Leishmaniasis, Marine sponge, Renieramycin A",
author = "Yoichi Nakao and Takeru Shiroiwa and Shuhei Murayama and Shigeki Matsunaga and Yasuyuki Goto and Yoshitsugu Matsumoto and Nobuhiro Fusetani",
note = "Publisher Copyright: {\textcopyright} 2004 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.",
year = "2004",
month = jun,
doi = "10.3390/md202055",
language = "English",
volume = "2",
pages = "55--62",
journal = "Marine Drugs",
issn = "1660-3397",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",
}