Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.

Yoichi Nakao; Takeru Shiroiwa; Shuhei Murayama; Shigeki Matsunaga; Yasuyuki Goto; Yoshitsugu Matsumoto; Nobuhiro Fusetani

doi:10.3390/md202055

Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.

Yoichi Nakao
, Takeru Shiroiwa
, Shuhei Murayama
, Shigeki Matsunaga
, Yasuyuki Goto
, Yoshitsugu Matsumoto
, Nobuhiro Fusetani^*

^*この研究の対応する著者

研究成果: Article › 査読

52 被引用数 (Scopus)

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The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC₅₀ value of 0.2 µg/mL.

本文言語	English
ページ（範囲）	55-62
ページ数	8
ジャーナル	Marine Drugs
巻	2
号	2
DOI	https://doi.org/10.3390/md202055
出版ステータス	Published - 2004 6月
外部発表	はい

ASJC Scopus subject areas

薬科学
創薬
薬理学、毒性学および薬学（その他）

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title = "Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.",

abstract = "The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 µg/mL.",

keywords = "Leishmaniasis, Marine sponge, Renieramycin A",

author = "Yoichi Nakao and Takeru Shiroiwa and Shuhei Murayama and Shigeki Matsunaga and Yasuyuki Goto and Yoshitsugu Matsumoto and Nobuhiro Fusetani",

note = "Publisher Copyright: {\textcopyright} 2004 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.",

year = "2004",

month = jun,

doi = "10.3390/md202055",

language = "English",

volume = "2",

pages = "55--62",

journal = "Marine Drugs",

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TY - JOUR

T1 - Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.

AU - Nakao, Yoichi

AU - Shiroiwa, Takeru

AU - Murayama, Shuhei

AU - Matsunaga, Shigeki

AU - Goto, Yasuyuki

AU - Matsumoto, Yoshitsugu

AU - Fusetani, Nobuhiro

PY - 2004/6

Y1 - 2004/6

N2 - The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 µg/mL.

AB - The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 µg/mL.

KW - Leishmaniasis

KW - Marine sponge

KW - Renieramycin A

UR - https://www.scopus.com/pages/publications/33645828161

UR - https://www.scopus.com/pages/publications/33645828161#tab=citedBy

U2 - 10.3390/md202055

DO - 10.3390/md202055

M3 - Article

AN - SCOPUS:33645828161

SN - 1660-3397

VL - 2

SP - 55

EP - 62

JO - Marine Drugs

JF - Marine Drugs

IS - 2

ER -

Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.

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