TY - JOUR
T1 - In Vivo Gold Complex Catalysis within Live Mice
AU - Tsubokura, Kazuki
AU - Vong, Kenward K.H.
AU - Pradipta, Ambara R.
AU - Ogura, Akihiro
AU - Urano, Sayaka
AU - Tahara, Tsuyoshi
AU - Nozaki, Satoshi
AU - Onoe, Hirotaka
AU - Nakao, Yoichi
AU - Sibgatullina, Regina
AU - Kurbangalieva, Almira
AU - Watanabe, Yasuyoshi
AU - Tanaka, Katsunori
N1 - Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/3/20
Y1 - 2017/3/20
N2 - Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin–AuIII complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.
AB - Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin–AuIII complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.
KW - amide bond formation
KW - fluorescent labeling
KW - glycoalbumin
KW - gold catalysis
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U2 - 10.1002/anie.201610273
DO - 10.1002/anie.201610273
M3 - Article
C2 - 28198119
AN - SCOPUS:85013635648
SN - 1433-7851
VL - 56
SP - 3579
EP - 3584
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 13
ER -