TY - JOUR
T1 - Influence of Ginkgo biloba extract feeding on blood pressure, heart rate, blood glucose, and various hepatic parameters in spontaneously hypertensive rats
AU - Umegaki, Keizo
AU - Yoshimura, Mika
AU - Higuchi, Mitsuru
AU - Esashi, Takatoshi
AU - Shinozuka, Kazumasa
PY - 2000
Y1 - 2000
N2 - We examined the effects of Ginkgo biloba extract (GBE) feeding on blood pressure, heart rate, blood glucose, and various hepatic parameters in spontaneously hypertensive rats (SHR). Male SHR (10 weeks old) were fed either a control diet or diet containing GBE (0.5% and 2% w/w) for 36 days. Average intakes of GBE in the 0.5% and 2% GBE diet groups were about 0.3 g/kg body weight/day and 1.3 g/kg body weight/day, respectively. The blood pressure and heart rate were continuously measured by a telemetric method, and showed a clear circadian rhythm (high at night and low in daytime). The heart rate both at night and in daytime was lowered in the 2% GBE diet group within a few days. The feeding of the GBE diet did not influence the systolic or diastolic blood pressure, blood glucose, or plasma insulin. However, the feeding of GBE diet increased liver weight in a GBE dose-dependent manner, and enhanced phospholipids concentration in the liver. In addition, feeding of the GBE diet markedly increased the content of cytochrome P-450, and the activity of glutathione S-transferase in the liver. Plasma transaminase activity was unaltered by the feeding of GBE diet. These results suggest that feeding of GBE to SHR had no beneficial effect on the parameters examined, but also had no obvious toxicity, even at a high dose of GBE.
AB - We examined the effects of Ginkgo biloba extract (GBE) feeding on blood pressure, heart rate, blood glucose, and various hepatic parameters in spontaneously hypertensive rats (SHR). Male SHR (10 weeks old) were fed either a control diet or diet containing GBE (0.5% and 2% w/w) for 36 days. Average intakes of GBE in the 0.5% and 2% GBE diet groups were about 0.3 g/kg body weight/day and 1.3 g/kg body weight/day, respectively. The blood pressure and heart rate were continuously measured by a telemetric method, and showed a clear circadian rhythm (high at night and low in daytime). The heart rate both at night and in daytime was lowered in the 2% GBE diet group within a few days. The feeding of the GBE diet did not influence the systolic or diastolic blood pressure, blood glucose, or plasma insulin. However, the feeding of GBE diet increased liver weight in a GBE dose-dependent manner, and enhanced phospholipids concentration in the liver. In addition, feeding of the GBE diet markedly increased the content of cytochrome P-450, and the activity of glutathione S-transferase in the liver. Plasma transaminase activity was unaltered by the feeding of GBE diet. These results suggest that feeding of GBE to SHR had no beneficial effect on the parameters examined, but also had no obvious toxicity, even at a high dose of GBE.
KW - Blood glucose
KW - Drug-metabolizing enzyme
KW - Ginkgo biloba extract
KW - Heart rate
KW - SHR
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M3 - Article
AN - SCOPUS:0033943936
SN - 0015-6426
VL - 41
SP - 171
EP - 177
JO - Journal of the Food Hygienic Society of Japan
JF - Journal of the Food Hygienic Society of Japan
IS - 3
ER -