TY - JOUR
T1 - Inhibition of IgG-, F(ab')2- and myeloma protein-induced erythrocyte aggregation, by small IgG-fragments
AU - Imaizumi, Kazuhiko
AU - Imai, Atsuko
AU - Maruyama, Tohru
AU - Shiga, Takeshi
PY - 1984
Y1 - 1984
N2 - The velocity of non-immune erythrocyte aggregation was determined by means of an automated rheoscope, consisted of an inverted microscope, a cone-plate viscometer, a TV image analyzer and a computer, in autologous plasma at a shear rate of 7.5/sec. As increasing the concentration of IgG and F(ab')2 added to diluted plasma, the velocity of aggregation increased, resembling the accelerated aggregation in 5 cases of multiple myeloma. Fab- and Fc-fragments scarcely affected the velocity; on contrary, they inhibited the aggregation induced by IgG or F(ab')2 as well as in multiple myeloma. As a plausible explanation of such inhibition, a competitive mechanism is suggested.
AB - The velocity of non-immune erythrocyte aggregation was determined by means of an automated rheoscope, consisted of an inverted microscope, a cone-plate viscometer, a TV image analyzer and a computer, in autologous plasma at a shear rate of 7.5/sec. As increasing the concentration of IgG and F(ab')2 added to diluted plasma, the velocity of aggregation increased, resembling the accelerated aggregation in 5 cases of multiple myeloma. Fab- and Fc-fragments scarcely affected the velocity; on contrary, they inhibited the aggregation induced by IgG or F(ab')2 as well as in multiple myeloma. As a plausible explanation of such inhibition, a competitive mechanism is suggested.
KW - Erythrocyte Aggregation
KW - IgG-fragments
KW - Immunoglobulin
KW - Multiple Myeloma
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M3 - Article
AN - SCOPUS:0021169603
SN - 1386-0291
VL - 4
SP - 431
EP - 439
JO - Clinical Hemorheology and Microcirculation
JF - Clinical Hemorheology and Microcirculation
IS - 4
ER -