Interaction between intrinsically disordered proteins Praja1 and α-synuclein on gold electrodes

Wataru Mori; Wataru Onodera; Terutoshi Kojima; Toru Asahi; Takuya Nakanishi

doi:10.1093/chemle/upae205

Interaction between intrinsically disordered proteins Praja1 and α-synuclein on gold electrodes

Wataru Mori, Wataru Onodera, Terutoshi Kojima, Toru Asahi^*, Takuya Nakanishi^*

^*この研究の対応する著者

研究成果: Article › 査読

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The behavior of Praja1 (PJA1) interacting with alpha-synuclein (α-Syn) on a gold electrode was investigated using electrochemical methods, where both PJA1 and α-Syn are intrinsically disordered proteins. From the electrode reaction of ferricyanide ions added as probe, it was suggested that PJA1 interacts with α-Syn even when adsorbed on gold substrate and that the state of PJA1 on gold electrodes can be classified into four categories depending on the α-Syn concentration.

本文言語	English
論文番号	upae205
ジャーナル	Chemistry Letters
巻	53
号	11
DOI	https://doi.org/10.1093/chemle/upae205
出版ステータス	Published - 2024 11月 1

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化学一般

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10.1093/chemle/upae205

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title = "Interaction between intrinsically disordered proteins Praja1 and α-synuclein on gold electrodes",

abstract = "The behavior of Praja1 (PJA1) interacting with alpha-synuclein (α-Syn) on a gold electrode was investigated using electrochemical methods, where both PJA1 and α-Syn are intrinsically disordered proteins. From the electrode reaction of ferricyanide ions added as probe, it was suggested that PJA1 interacts with α-Syn even when adsorbed on gold substrate and that the state of PJA1 on gold electrodes can be classified into four categories depending on the α-Syn concentration.",

keywords = "gold electrode, intrinsically disordered proteins, protein–protein interactions",

author = "Wataru Mori and Wataru Onodera and Terutoshi Kojima and Toru Asahi and Takuya Nakanishi",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of the Chemical Society of Japan.",

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doi = "10.1093/chemle/upae205",

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AU - Mori, Wataru

AU - Onodera, Wataru

AU - Kojima, Terutoshi

AU - Asahi, Toru

AU - Nakanishi, Takuya

N1 - Publisher Copyright: © The Author(s) 2024. Published by Oxford University Press on behalf of the Chemical Society of Japan.

PY - 2024/11/1

Y1 - 2024/11/1

N2 - The behavior of Praja1 (PJA1) interacting with alpha-synuclein (α-Syn) on a gold electrode was investigated using electrochemical methods, where both PJA1 and α-Syn are intrinsically disordered proteins. From the electrode reaction of ferricyanide ions added as probe, it was suggested that PJA1 interacts with α-Syn even when adsorbed on gold substrate and that the state of PJA1 on gold electrodes can be classified into four categories depending on the α-Syn concentration.

AB - The behavior of Praja1 (PJA1) interacting with alpha-synuclein (α-Syn) on a gold electrode was investigated using electrochemical methods, where both PJA1 and α-Syn are intrinsically disordered proteins. From the electrode reaction of ferricyanide ions added as probe, it was suggested that PJA1 interacts with α-Syn even when adsorbed on gold substrate and that the state of PJA1 on gold electrodes can be classified into four categories depending on the α-Syn concentration.

KW - gold electrode

KW - intrinsically disordered proteins

KW - protein–protein interactions

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JO - Chemistry Letters

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Interaction between intrinsically disordered proteins Praja1 and α-synuclein on gold electrodes

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