Interactions of functionalized polymeric liposomes having a porphinato-iron complex with some biological cells and components in vitro

Etsuo Hasegawa; Kiyoshi Eshima; Yoh Ichi Matsushita; Hiroyuki Nishide; Eishun Tsuchida

doi:10.1016/0005-2736(86)90224-5

Interactions of functionalized polymeric liposomes having a porphinato-iron complex with some biological cells and components in vitro

Etsuo Hasegawa, Kiyoshi Eshima, Yoh Ichi Matsushita, Hiroyuki Nishide, Eishun Tsuchida^*

^*この研究の対応する著者

理工学術院総合研究所

研究成果: Article › 査読

12 被引用数 (Scopus)

抄録

The hemocompatibility of functionalized polymeric liposome particles (diameter: 20-32 nm), which have a synthetic porphinato-iron complex in their polymerized bilayers and can carry oxygen, was studied in vitro. The ultramicroparticles did not induce hemolysis, platelet aggregation and plasma coagulation directly and were stable against hydrolysis by phospholipases A₂ and D.

本文言語	English
ページ（範囲）	235-242
ページ数	8
ジャーナル	BBA - Biomembranes
巻	862
号	2
DOI	https://doi.org/10.1016/0005-2736(86)90224-5
出版ステータス	Published - 1986 11月 17

ASJC Scopus subject areas

生化学
生物理学
細胞生物学

文献へのアクセス

10.1016/0005-2736(86)90224-5

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引用スタイル

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keywords = "Hemocompatibility, Hemolysis, Liposome, Phospholipase, Plasma coagulation, Platelet aggregation, Polymeric liposome",

author = "Etsuo Hasegawa and Kiyoshi Eshima and Matsushita, {Yoh Ichi} and Hiroyuki Nishide and Eishun Tsuchida",

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AU - Hasegawa, Etsuo

AU - Eshima, Kiyoshi

AU - Matsushita, Yoh Ichi

AU - Nishide, Hiroyuki

AU - Tsuchida, Eishun

PY - 1986/11/17

Y1 - 1986/11/17

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AB - The hemocompatibility of functionalized polymeric liposome particles (diameter: 20-32 nm), which have a synthetic porphinato-iron complex in their polymerized bilayers and can carry oxygen, was studied in vitro. The ultramicroparticles did not induce hemolysis, platelet aggregation and plasma coagulation directly and were stable against hydrolysis by phospholipases A2 and D.

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KW - Hemolysis

KW - Liposome

KW - Phospholipase

KW - Plasma coagulation

KW - Platelet aggregation

KW - Polymeric liposome

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