@article{ea008df49fe84024b1758e4ab1cda66b,
title = "Involvement of strawberry notch homologue 1 in neurite outgrowth of cortical neurons",
abstract = "When the regulation of axonal and dendritic growth is altered, the neuronal network becomes disordered, which may contribute to the development of psychiatric disorders. Some genome analyses have suggested relationships between mutations in strawberry notch homologue 1 (SBNO1) and neurodevelopmental disorders. However, the function of SBNO1 has not yet been reported. Here, SBNO1 expression pattern during the development of the cerebral cortex in mice was examined. SBNO1 was strongly expressed in the cortical plate and its expression was maintained at a low level during the postnatal stage. CRISPR/Cas9-based knockout of Sbno1 in Neuro2A cultured cells showed delayed growth of neurites. A cortical neuron-specific conditional knockout mouse was constructed, which resulted in hypotrophy of axon bundles and dendrites in cortical neurons. Thus, when mutated, SBNO1 is a candidate gene for psychiatric diseases, such as schizophrenia, as suggested by human genome studies.",
keywords = "Nex-Cre, cortical neurons, cortical plate, neurite growth, strawberry notch",
author = "Munkhsoyol Erkhembaatar and Iroha Yamamoto and Fuduki Inoguchi and Kosuke Taki and Satoru Yamagishi and Leanne Delaney and Nishibe Mariko and Takaya Abe and Hiroshi Kiyonari and Carina Hanashima and Hayato Naka-kaneda and Dai Ihara and Yu Katsuyama",
note = "Funding Information: We thank all members of the Division of Neuroanatomy, Department of Anatomy, Shiga University of Medical Science. We thank the Research Center for Animal Science, Shiga University of Medical Science, Japan. We also thank Dr. Shinichi Aizawa for helping construct the floxed mouse strain. This cell line was provided by Dr. Masaki Mori. This study was supported by research grants KAKENHI 18K06502 and 21K06408 to Yu Katsuyama and 20K22735 to Dai Ihara. Sbno1 Funding Information: We thank all members of the Division of Neuroanatomy, Department of Anatomy, Shiga University of Medical Science. We thank the Research Center for Animal Science, Shiga University of Medical Science, Japan. We also thank Dr. Shinichi Aizawa for helping construct the floxed Sbno1 mouse strain. This cell line was provided by Dr. Masaki Mori. This study was supported by research grants KAKENHI 18K06502 and 21K06408 to Yu Katsuyama and 20K22735 to Dai Ihara. Publisher Copyright: {\textcopyright} 2022 Japanese Society of Developmental Biologists.",
year = "2022",
month = sep,
doi = "10.1111/dgd.12802",
language = "English",
volume = "64",
pages = "379--394",
journal = "Development Growth and Differentiation",
issn = "0012-1592",
publisher = "Wiley-Blackwell",
number = "7",
}