Involvement of strawberry notch homologue 1 in neurite outgrowth of cortical neurons

Munkhsoyol Erkhembaatar, Iroha Yamamoto, Fuduki Inoguchi, Kosuke Taki, Satoru Yamagishi, Leanne Delaney, Nishibe Mariko, Takaya Abe, Hiroshi Kiyonari, Carina Hanashima, Hayato Naka-kaneda, Dai Ihara, Yu Katsuyama*


研究成果: Article査読


When the regulation of axonal and dendritic growth is altered, the neuronal network becomes disordered, which may contribute to the development of psychiatric disorders. Some genome analyses have suggested relationships between mutations in strawberry notch homologue 1 (SBNO1) and neurodevelopmental disorders. However, the function of SBNO1 has not yet been reported. Here, SBNO1 expression pattern during the development of the cerebral cortex in mice was examined. SBNO1 was strongly expressed in the cortical plate and its expression was maintained at a low level during the postnatal stage. CRISPR/Cas9-based knockout of Sbno1 in Neuro2A cultured cells showed delayed growth of neurites. A cortical neuron-specific conditional knockout mouse was constructed, which resulted in hypotrophy of axon bundles and dendrites in cortical neurons. Thus, when mutated, SBNO1 is a candidate gene for psychiatric diseases, such as schizophrenia, as suggested by human genome studies.

ジャーナルDevelopment Growth and Differentiation
出版ステータスPublished - 2022 9月

ASJC Scopus subject areas

  • 発生生物学
  • 細胞生物学


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