Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii

Fumiaki Nakamura; Hiroshi Maejima; Midori Kawamura; Daisuke Arai; Tatsufumi Okino; Meng Zhao; Tao Ye; Jungyeol Lee; Young Tae Chang; Nobuhiro Fusetani; Yoichi Nakao

doi:10.1016/j.bmcl.2018.04.067

Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii

Fumiaki Nakamura, Hiroshi Maejima, Midori Kawamura, Daisuke Arai, Tatsufumi Okino, Meng Zhao, Tao Ye, Jungyeol Lee, Young Tae Chang, Nobuhiro Fusetani, Yoichi Nakao^*

^*この研究の対応する著者

研究成果: Article › 査読

10 被引用数 (Scopus)

抄録

Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.

本文言語	English
ページ（範囲）	2206-2209
ページ数	4
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	28
号	12
DOI	https://doi.org/10.1016/j.bmcl.2018.04.067
出版ステータス	Published - 2018 7月 1

ASJC Scopus subject areas

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1016/j.bmcl.2018.04.067

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引用スタイル

Nakamura, F., Maejima, H., Kawamura, M., Arai, D., Okino, T., Zhao, M., Ye, T., Lee, J., Chang, Y. T., Fusetani, N., & Nakao, Y. (2018). Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii. Bioorganic and Medicinal Chemistry Letters, 28(12), 2206-2209. https://doi.org/10.1016/j.bmcl.2018.04.067

Nakamura, F, Maejima, H, Kawamura, M, Arai, D, Okino, T, Zhao, M, Ye, T, Lee, J, Chang, YT, Fusetani, N & Nakao, Y 2018, 'Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii', Bioorganic and Medicinal Chemistry Letters, vol. 28, no. 12, pp. 2206-2209. https://doi.org/10.1016/j.bmcl.2018.04.067

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abstract = "Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.",

keywords = "Astrocyte differentiation, Cyanobacterium, Marine natural products, Neural stem cells, Pentapeptide",

author = "Fumiaki Nakamura and Hiroshi Maejima and Midori Kawamura and Daisuke Arai and Tatsufumi Okino and Meng Zhao and Tao Ye and Jungyeol Lee and Chang, {Young Tae} and Nobuhiro Fusetani and Yoichi Nakao",

note = "Funding Information: We appreciate Prof. K. Hori, Dr. M. Hirayama, and the crews of R/V Toyoshiomaru of Hiroshima University for their support in the sample collection. We are also thankful for Emeritus Prof. J. Kimura of Aoyama Gakuin University for providing synthetic samples of Amha. This paper is a part of the outcome of research performed under a Waseda University Grant-in-Aid for Scientific Research, the Strategic Research Platforms for Private University, a Matching Fund Subsidy from the Ministry of Education, Science, Sports, and Technology (MEXT), Japan, and JSPS KAKENHI Grant Numbers 26221204, 25303008, and 19310138; Shenzhen Peacock Plan (KQTD2015071714043444). This work was supported by JSPS Core-to-Core Program, A. Advanced Research Networks. This work was inspired by the international and interdisciplinary environments of the JSPS Asian CORE Program, Asian Chemical Biology Initiative (ACBI) and JSPS A3 Foresight Program. Publisher Copyright: {\textcopyright} 2018",

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AU - Okino, Tatsufumi

AU - Zhao, Meng

AU - Ye, Tao

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AU - Chang, Young Tae

AU - Fusetani, Nobuhiro

AU - Nakao, Yoichi

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