Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa

Yoichi Nakao; Wesley Y. Yoshida; Yuuki Takada; Junji Kimura; Liu Yang; Susan L. Mooberry; Paul J. Scheuer

doi:10.1021/np049949f

Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa

Yoichi Nakao^*, Wesley Y. Yoshida, Yuuki Takada, Junji Kimura, Liu Yang, Susan L. Mooberry, Paul J. Scheuer

^*この研究の対応する著者

研究成果: Article › 査読

70 被引用数 (Scopus)

抄録

A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC₅₀ values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.

本文言語	English
ページ（範囲）	1332-1340
ページ数	9
ジャーナル	Journal of Natural Products
巻	67
号	8
DOI	https://doi.org/10.1021/np049949f
出版ステータス	Published - 2004 8月
外部発表	はい

ASJC Scopus subject areas

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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title = "Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa",

abstract = "A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.",

author = "Yoichi Nakao and Yoshida, {Wesley Y.} and Yuuki Takada and Junji Kimura and Liu Yang and Mooberry, {Susan L.} and Scheuer, {Paul J.}",

year = "2004",

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doi = "10.1021/np049949f",

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journal = "Journal of Natural Products",

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AU - Nakao, Yoichi

AU - Yoshida, Wesley Y.

AU - Takada, Yuuki

AU - Kimura, Junji

AU - Yang, Liu

AU - Mooberry, Susan L.

AU - Scheuer, Paul J.

PY - 2004/8

Y1 - 2004/8

N2 - A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.

AB - A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.

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JO - Journal of Natural Products

JF - Journal of Natural Products

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ER -

Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa

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ASJC Scopus subject areas

UN SDG

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