Lanthanide metal complexes for the hydrolysis of linear DNAs

Tetsuro Shiiba; Koji Yonezawa; Naoya Takeda; Yoichi Matsumoto; Morio Yashiro; Makoto Komiyama

doi:10.1016/0304-5102(93)80079-A

Lanthanide metal complexes for the hydrolysis of linear DNAs

Tetsuro Shiiba, Koji Yonezawa, Naoya Takeda, Yoichi Matsumoto, Morio Yashiro, Makoto Komiyama^*

^*この研究の対応する著者

研究成果: Letter › 査読

42 被引用数 (Scopus)

抄録

Lanthanum (III) and cerium (III) complexes of macrocyclic ligands efficiently hydrolyze the phosphodiester linkages in linear DNAs at pH 7.2 and 30-50°C. Both single-stranded and double-stranded DNAs are hydrolysed without specific base preference, yielding predominantly 3′-phosphate termini. The potential of these complexes as the catalytic centers of artificial hydrolytic nucleases are indicated.

本文言語	English
ページ（範囲）	L21-L25
ジャーナル	Journal of Molecular Catalysis
巻	84
号	1
DOI	https://doi.org/10.1016/0304-5102(93)80079-A
出版ステータス	Published - 1993 9月 21
外部発表	はい

ASJC Scopus subject areas

工学（全般）

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10.1016/0304-5102(93)80079-A

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title = "Lanthanide metal complexes for the hydrolysis of linear DNAs",

abstract = "Lanthanum (III) and cerium (III) complexes of macrocyclic ligands efficiently hydrolyze the phosphodiester linkages in linear DNAs at pH 7.2 and 30-50°C. Both single-stranded and double-stranded DNAs are hydrolysed without specific base preference, yielding predominantly 3′-phosphate termini. The potential of these complexes as the catalytic centers of artificial hydrolytic nucleases are indicated.",

keywords = "DNA hydrolysis, artificial nuclease, cerium (III) complex, lanthanide (III) complex, lanthanum (III) complex",

author = "Tetsuro Shiiba and Koji Yonezawa and Naoya Takeda and Yoichi Matsumoto and Morio Yashiro and Makoto Komiyama",

year = "1993",

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doi = "10.1016/0304-5102(93)80079-A",

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T1 - Lanthanide metal complexes for the hydrolysis of linear DNAs

AU - Shiiba, Tetsuro

AU - Yonezawa, Koji

AU - Takeda, Naoya

AU - Matsumoto, Yoichi

AU - Yashiro, Morio

AU - Komiyama, Makoto

PY - 1993/9/21

Y1 - 1993/9/21

N2 - Lanthanum (III) and cerium (III) complexes of macrocyclic ligands efficiently hydrolyze the phosphodiester linkages in linear DNAs at pH 7.2 and 30-50°C. Both single-stranded and double-stranded DNAs are hydrolysed without specific base preference, yielding predominantly 3′-phosphate termini. The potential of these complexes as the catalytic centers of artificial hydrolytic nucleases are indicated.

AB - Lanthanum (III) and cerium (III) complexes of macrocyclic ligands efficiently hydrolyze the phosphodiester linkages in linear DNAs at pH 7.2 and 30-50°C. Both single-stranded and double-stranded DNAs are hydrolysed without specific base preference, yielding predominantly 3′-phosphate termini. The potential of these complexes as the catalytic centers of artificial hydrolytic nucleases are indicated.

KW - DNA hydrolysis

KW - artificial nuclease

KW - cerium (III) complex

KW - lanthanide (III) complex

KW - lanthanum (III) complex

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UR - http://www.scopus.com/inward/citedby.url?scp=0027663848&partnerID=8YFLogxK

U2 - 10.1016/0304-5102(93)80079-A

DO - 10.1016/0304-5102(93)80079-A

M3 - Letter

AN - SCOPUS:0027663848

SN - 0304-5102

VL - 84

SP - L21-L25

JO - Journal of Molecular Catalysis

JF - Journal of Molecular Catalysis

IS - 1

ER -

Lanthanide metal complexes for the hydrolysis of linear DNAs

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