Linear and non-linear associations of device-measured sedentary time with older adults' skeletal muscle mass

Ai Shibata*, Kaori Ishii, Mohammad Javad Koohsari, Takemi Sugiyama, David W. Dunstan, Neville Owen, Koichiro Oka


研究成果: Article査読

1 被引用数 (Scopus)


Background: Time spent sitting is associated adversely with health outcomes in older adults. Nevertheless, it is not clear how sedentary time may be related to appendicular skeletal muscle mass (ASM) – a key attribute of sarcopenia. This cross-sectional study examined associations of total sedentary time with ASM among community-dwelling older Japanese males and females. Methods: Participants (n = 281, 74.3 ± 5.2 yr) wore a tri-axial accelerometer for seven days. Body mass index-adjusted ASM (kg/BMI) was derived from bioimpedance measures. Multivariate linear and quadratic regression models examined the associations of ASM with total sedentary time, stratified by sex. Restricted cubic spline models were fitted to estimate non-linear associations. Isotemporal substitution (IS) models were used to estimate the impacts of replacing 30-minute of sedentary time with light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA). Results: After adjustment, total sedentary time had a significant linear and negative association with ASM among females (β = −0.014; p = 0.023). For males, total sedentary time had a significant quadratic association (p = 0.020). Spline models indicated a reverse U-shaped association (p < 0.001) with total sedentary time over 9.3 h/day being associated with lower ASM. The IS models indicated that replacing 30 min/day of sedentary time with LPA would be positively and significantly associated with older females' ASM (β = 0.007, p = 0.022). Conclusions: In older Japanese adults, higher volumes of time spent sedentary were associated with lower ASM. For males, only very high volumes of sedentary time appeared to be detrimental. These adverse relationships may in part be offset by more time spent in either LPA or MVPA.

ジャーナルExperimental Gerontology
出版ステータスPublished - 2022 9月

ASJC Scopus subject areas

  • 生化学
  • 加齢科学
  • 分子生物学
  • 遺伝学
  • 内分泌学
  • 細胞生物学


「Linear and non-linear associations of device-measured sedentary time with older adults' skeletal muscle mass」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。