Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model

Shotaro Yasuda; Sho Higano; Atsushi Ishiyama; Yumie Ono; Ichige Kajimura; Susumu Minamisawa

doi:10.1109/EMBC.2015.7319388

Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model

Shotaro Yasuda, Sho Higano, Atsushi Ishiyama, Yumie Ono, Ichige Kajimura, Susumu Minamisawa

研究成果: Conference contribution

抄録

Utilizing small animal magnetocardiograms (MCG), we have developed a diagnostic method to detect the development of pulmonary hypertension (PH) in a rat heart. We obtained multiple MCG of rats with monocrotaline-induced PH and monitored the development of pathophysiological conditions. Current dipole estimation was then applied to determine the association between abnormal propagation of the cardiac excited wavefront and disease states. The progress of right ventricular hypertrophy correlated with a decrease in the angles of the current dipoles during R and S waves. In addition, clear changes in the current dipole angles during S waves were observed 9-19 days before the availability of echocardiographic diagnosis of the PH. Our results showed, using a rat PH model, that continuous monitoring of myocardial conditions allows PH to be detected at an earlier stage than echocardiographic screening.

本文言語	English
ホスト出版物のタイトル	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
出版社	Institute of Electrical and Electronics Engineers Inc.
ページ	4475-4478
ページ数	4
巻	2015-November
ISBN（印刷版）	9781424492718
DOI	https://doi.org/10.1109/EMBC.2015.7319388
出版ステータス	Published - 2015 11月 4
イベント	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy 継続期間: 2015 8月 25 → 2015 8月 29

Other

Other	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
国/地域	Italy
City	Milan
Period	15/8/25 → 15/8/29

ASJC Scopus subject areas

コンピュータビジョンおよびパターン認識
信号処理
生体医工学
健康情報学

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10.1109/EMBC.2015.7319388

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引用スタイル

Yasuda, S., Higano, S., Ishiyama, A., Ono, Y., Kajimura, I., & Minamisawa, S. (2015). Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 4475-4478). 記事 7319388 Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319388

Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model. / Yasuda, Shotaro; Higano, Sho; Ishiyama, Atsushi その他.
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 4475-4478 7319388.

研究成果: Conference contribution

Yasuda, S, Higano, S, Ishiyama, A, Ono, Y, Kajimura, I & Minamisawa, S 2015, Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2015-November, 7319388, Institute of Electrical and Electronics Engineers Inc., pp. 4475-4478, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 15/8/25. https://doi.org/10.1109/EMBC.2015.7319388

Yasuda S, Higano S, Ishiyama A, Ono Y, Kajimura I, Minamisawa S. Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November. Institute of Electrical and Electronics Engineers Inc. 2015. p. 4475-4478. 7319388 doi: 10.1109/EMBC.2015.7319388

Yasuda, Shotaro ; Higano, Sho ; Ishiyama, Atsushi その他. / Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. pp. 4475-4478

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abstract = "Utilizing small animal magnetocardiograms (MCG), we have developed a diagnostic method to detect the development of pulmonary hypertension (PH) in a rat heart. We obtained multiple MCG of rats with monocrotaline-induced PH and monitored the development of pathophysiological conditions. Current dipole estimation was then applied to determine the association between abnormal propagation of the cardiac excited wavefront and disease states. The progress of right ventricular hypertrophy correlated with a decrease in the angles of the current dipoles during R and S waves. In addition, clear changes in the current dipole angles during S waves were observed 9-19 days before the availability of echocardiographic diagnosis of the PH. Our results showed, using a rat PH model, that continuous monitoring of myocardial conditions allows PH to be detected at an earlier stage than echocardiographic screening.",

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Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model

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