TY - JOUR
T1 - Multiple purpose simulator using a natural porcine mitral valve
AU - Arita, Makoto
AU - Tono, Sumihiro
AU - Kasegawa, Hitoshi
AU - Umezu, Mitsuo
N1 - Funding Information:
This research was carried out with the aid of the following research funds: The Program for Promotion of Fundamental Studies in Health Science of the Organization for Drug ADR Relief, R&D Promotion and Product Review of Japan (No.96–12); Grant-in-aid for Scientific Research of Japan (No.09557112, No.09470288); and Health Sciences Research Grants (No.H-11-Drug-006). The authors would like to express their gratitude to Mr. Dave Myers of Medtronic Heart Valves, for reviewing the manuscript. Also, we are very thankful to Mr. Tomoya Mizunuma, undergraduate students in Prof. Umezu's laboratory, who provided much valuable assistance in the performance of these experiments.
PY - 2004/12
Y1 - 2004/12
N2 - An in vitro pulsatile simulator with a porcine mitral valve was developed in order to simulate physiologic and diseased mitral valve conditions. Evaluation of these conditions was conducted from a hydrodynamic and annulus behavior point of view. We found it possible to simulate mild "mitral valve prolapse" and to obtain quantitative data related to the condition. The diseased condition produced a 40% greater regurgitant volume than that observed under the normal condition (p < 0.0001). Regarding the leakage volume, the diseased condition exhibited about 2.6 times more leakage than the normal condition. The mitral valve simulator proposed in this study is considered fairly stable with respect to both hemodynamics and the behavior of the annulus, and it is an adequate simulator for modeling various types of normal and diseased mitral valve conditions.
AB - An in vitro pulsatile simulator with a porcine mitral valve was developed in order to simulate physiologic and diseased mitral valve conditions. Evaluation of these conditions was conducted from a hydrodynamic and annulus behavior point of view. We found it possible to simulate mild "mitral valve prolapse" and to obtain quantitative data related to the condition. The diseased condition produced a 40% greater regurgitant volume than that observed under the normal condition (p < 0.0001). Regarding the leakage volume, the diseased condition exhibited about 2.6 times more leakage than the normal condition. The mitral valve simulator proposed in this study is considered fairly stable with respect to both hemodynamics and the behavior of the annulus, and it is an adequate simulator for modeling various types of normal and diseased mitral valve conditions.
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U2 - 10.1177/021849230401200415
DO - 10.1177/021849230401200415
M3 - Article
C2 - 15585707
AN - SCOPUS:10444237252
SN - 0218-4923
VL - 12
SP - 350
EP - 356
JO - Asian Cardiovascular and Thoracic Annals
JF - Asian Cardiovascular and Thoracic Annals
IS - 4
ER -