Muscarinic receptor occupancy by biperiden in living human brain

Yasuhiko Sudo; Tetsuya Suhara; Kazutoshi Suzuki; Yoshiro Okubo; Kyosan Yoshikawa; Sunao Uchida; Takeshi Sassa; Takashi Okauchi; Yasuhito Sasaki; Masaaki Matsushita

Muscarinic receptor occupancy by biperiden in living human brain

Yasuhiko Sudo^*, Tetsuya Suhara, Kazutoshi Suzuki, Yoshiro Okubo, Kyosan Yoshikawa, Sunao Uchida, Takeshi Sassa, Takashi Okauchi, Yasuhito Sasaki, Masaaki Matsushita

^*この研究の対応する著者

研究成果: Article › 査読

5 被引用数 (Scopus)

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Anticholinergic drug is often used to treat extrapyramidal symptoms. We measured muscarinic cholinergic receptor (mAchR) occupancy by the oral administration of biperiden in eight healthy subjects using positron emission tomography (PET) and [¹¹C]N-methyl-4-piperidylbenzilate (NMPB). After the baseline scan each subject underwent one or two post-dose PET scans, mAchR occupancy was 10-45% in the frontal cortex three hours after the oral administration of 4 mg of biperiden. The occupancy correlated with the plasma concentration of biperiden in a curvilinear manner.

本文言語	English
ジャーナル	Life Sciences
巻	64
号	8
出版ステータス	Published - 1999 1月 15
外部発表	はい

ASJC Scopus subject areas

薬理学

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title = "Muscarinic receptor occupancy by biperiden in living human brain",

abstract = "Anticholinergic drug is often used to treat extrapyramidal symptoms. We measured muscarinic cholinergic receptor (mAchR) occupancy by the oral administration of biperiden in eight healthy subjects using positron emission tomography (PET) and [11C]N-methyl-4-piperidylbenzilate (NMPB). After the baseline scan each subject underwent one or two post-dose PET scans, mAchR occupancy was 10-45% in the frontal cortex three hours after the oral administration of 4 mg of biperiden. The occupancy correlated with the plasma concentration of biperiden in a curvilinear manner.",

keywords = "Biperiden, Human, Muscarinic cholinergic receptor, Positron emission tomography",

author = "Yasuhiko Sudo and Tetsuya Suhara and Kazutoshi Suzuki and Yoshiro Okubo and Kyosan Yoshikawa and Sunao Uchida and Takeshi Sassa and Takashi Okauchi and Yasuhito Sasaki and Masaaki Matsushita",

year = "1999",

month = jan,

day = "15",

language = "English",

volume = "64",

journal = "Life Sciences",

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T1 - Muscarinic receptor occupancy by biperiden in living human brain

AU - Sudo, Yasuhiko

AU - Suhara, Tetsuya

AU - Suzuki, Kazutoshi

AU - Okubo, Yoshiro

AU - Yoshikawa, Kyosan

AU - Uchida, Sunao

AU - Sassa, Takeshi

AU - Okauchi, Takashi

AU - Sasaki, Yasuhito

AU - Matsushita, Masaaki

PY - 1999/1/15

Y1 - 1999/1/15

N2 - Anticholinergic drug is often used to treat extrapyramidal symptoms. We measured muscarinic cholinergic receptor (mAchR) occupancy by the oral administration of biperiden in eight healthy subjects using positron emission tomography (PET) and [11C]N-methyl-4-piperidylbenzilate (NMPB). After the baseline scan each subject underwent one or two post-dose PET scans, mAchR occupancy was 10-45% in the frontal cortex three hours after the oral administration of 4 mg of biperiden. The occupancy correlated with the plasma concentration of biperiden in a curvilinear manner.

AB - Anticholinergic drug is often used to treat extrapyramidal symptoms. We measured muscarinic cholinergic receptor (mAchR) occupancy by the oral administration of biperiden in eight healthy subjects using positron emission tomography (PET) and [11C]N-methyl-4-piperidylbenzilate (NMPB). After the baseline scan each subject underwent one or two post-dose PET scans, mAchR occupancy was 10-45% in the frontal cortex three hours after the oral administration of 4 mg of biperiden. The occupancy correlated with the plasma concentration of biperiden in a curvilinear manner.

KW - Biperiden

KW - Human

KW - Muscarinic cholinergic receptor

KW - Positron emission tomography

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M3 - Article

C2 - 10069534

AN - SCOPUS:0033556423

SN - 0024-3205

VL - 64

JO - Life Sciences

JF - Life Sciences

IS - 8

ER -

Muscarinic receptor occupancy by biperiden in living human brain

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