TY - JOUR
T1 - New tetrahydroquinoline and indoline compounds containing a hydroxy cyclopentenone, virantmycin B and C, produced by Streptomyces sp. AM-2504
AU - Kimura, Tōru
AU - Suga, Takuya
AU - Kameoka, Masanori
AU - Ueno, Minoru
AU - Inahashi, Yuki
AU - Matsuo, Hirotaka
AU - Iwatsuki, Masato
AU - Shigemura, Katsumi
AU - Shiomi, Kazuro
AU - Takahashi, Yōko
AU - Ōmura, Satoshi
AU - Nakashima, Takuji
N1 - Funding Information:
Acknowledgements This study was supported by funding from the Institute for Fermentation, Osaka (IFO), Japan. We are grateful to Dr Kenichiro Nagai and Ms Noriko Sato, School of Pharmacy, Kitasato University, for measurements of MS spectra and NMR spectral data.
Publisher Copyright:
© 2018, The Author(s) under exclusive licence to the Japan Antibiotics Research Association.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Two new antibiotics, designated virantmycin B (1) and C (2), were isolated from the cultured broth of Streptomyces sp. AM-2504. Compounds 1 and 2 were purified by Diaion HP-20, silica gel, and octadecylsilane chromatography, followed by high-performance liquid chromatography. The chemical structures of the new compounds, 1 and 2, were determined by nuclear magnetic resonance and mass spectrometry, as containing a terahydroquinoline and an indoline, respectively, each also containing a hydroxy cyclopentenone moiety. Both compounds demonstrated weak antimicrobial (both antibacterial and antifungal) activity and compound 1 also showed antiviral activity against the dengue virus, whereas compound 2 exhibited no antiviral properties.
AB - Two new antibiotics, designated virantmycin B (1) and C (2), were isolated from the cultured broth of Streptomyces sp. AM-2504. Compounds 1 and 2 were purified by Diaion HP-20, silica gel, and octadecylsilane chromatography, followed by high-performance liquid chromatography. The chemical structures of the new compounds, 1 and 2, were determined by nuclear magnetic resonance and mass spectrometry, as containing a terahydroquinoline and an indoline, respectively, each also containing a hydroxy cyclopentenone moiety. Both compounds demonstrated weak antimicrobial (both antibacterial and antifungal) activity and compound 1 also showed antiviral activity against the dengue virus, whereas compound 2 exhibited no antiviral properties.
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U2 - 10.1038/s41429-018-0117-0
DO - 10.1038/s41429-018-0117-0
M3 - Article
C2 - 30532036
AN - SCOPUS:85058196653
SN - 0021-8820
VL - 72
SP - 169
EP - 173
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 3
ER -
