Nickel-catalyzed addition of pyridine-N-oxides across alkynes

Kyalo Stephen Kanyiva; Yoshiaki Nakao; Tamejiro Hiyama

doi:10.1002/anie.200703758

Nickel-catalyzed addition of pyridine-N-oxides across alkynes

Kyalo Stephen Kanyiva^*, Yoshiaki Nakao, Tamejiro Hiyama

^*この研究の対応する著者

研究成果: Article › 査読

240 被引用数 (Scopus)

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(Chemical Equation Presented) An alternative to pyridine: Pyridine-N-oxides undergo direct C-H activation and add across alkynes under mild nickel catalysis to afford (E)-2-alkenylpyridine-N-oxides in modest to good yields with high selectivity. Subsequent deoxygenation and deoxygenative functionalization proceed smoothly to give a wide variety of 2-substituted pyridines. PCyp ₃ = tricyclopentylphosphine, cod = cyclooctadiene.

本文言語	English
ページ（範囲）	8872-8874
ページ数	3
ジャーナル	Angewandte Chemie - International Edition
巻	46
号	46
DOI	https://doi.org/10.1002/anie.200703758
出版ステータス	Published - 2007 12月 10
外部発表	はい

ASJC Scopus subject areas

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化学 (全般)

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title = "Nickel-catalyzed addition of pyridine-N-oxides across alkynes",

abstract = "(Chemical Equation Presented) An alternative to pyridine: Pyridine-N-oxides undergo direct C-H activation and add across alkynes under mild nickel catalysis to afford (E)-2-alkenylpyridine-N-oxides in modest to good yields with high selectivity. Subsequent deoxygenation and deoxygenative functionalization proceed smoothly to give a wide variety of 2-substituted pyridines. PCyp 3 = tricyclopentylphosphine, cod = cyclooctadiene.",

keywords = "Alkynes, C-C coupling, C-H activation, Nickel, Pyridine-N-oxides",

author = "Kanyiva, {Kyalo Stephen} and Yoshiaki Nakao and Tamejiro Hiyama",

year = "2007",

month = dec,

day = "10",

doi = "10.1002/anie.200703758",

language = "English",

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journal = "Angewandte Chemie - International Edition",

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T1 - Nickel-catalyzed addition of pyridine-N-oxides across alkynes

AU - Kanyiva, Kyalo Stephen

AU - Nakao, Yoshiaki

AU - Hiyama, Tamejiro

PY - 2007/12/10

Y1 - 2007/12/10

N2 - (Chemical Equation Presented) An alternative to pyridine: Pyridine-N-oxides undergo direct C-H activation and add across alkynes under mild nickel catalysis to afford (E)-2-alkenylpyridine-N-oxides in modest to good yields with high selectivity. Subsequent deoxygenation and deoxygenative functionalization proceed smoothly to give a wide variety of 2-substituted pyridines. PCyp 3 = tricyclopentylphosphine, cod = cyclooctadiene.

AB - (Chemical Equation Presented) An alternative to pyridine: Pyridine-N-oxides undergo direct C-H activation and add across alkynes under mild nickel catalysis to afford (E)-2-alkenylpyridine-N-oxides in modest to good yields with high selectivity. Subsequent deoxygenation and deoxygenative functionalization proceed smoothly to give a wide variety of 2-substituted pyridines. PCyp 3 = tricyclopentylphosphine, cod = cyclooctadiene.

KW - Alkynes

KW - C-C coupling

KW - C-H activation

KW - Nickel

KW - Pyridine-N-oxides

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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Nickel-catalyzed addition of pyridine-N-oxides across alkynes

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