Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

Kentaro Takada; Yoichi Nakao; Shigeki Matsunaga; Rob W.M. Van Soest; Nobuhiro Fusetani

doi:10.1021/np010480n

Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

Kentaro Takada, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest, Nobuhiro Fusetani^*

^*この研究の対応する著者

研究成果: Article › 査読

33 被引用数 (Scopus)

抄録

A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC₅₀ value of 0.46μg/mL.

本文言語	English
ページ（範囲）	411-413
ページ数	3
ジャーナル	Journal of Natural Products
巻	65
号	3
DOI	https://doi.org/10.1021/np010480n
出版ステータス	Published - 2002 4月 9
外部発表	はい

ASJC Scopus subject areas

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1021/np010480n

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AU - Van Soest, Rob W.M.

AU - Fusetani, Nobuhiro

PY - 2002/4/9

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AB - A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46μg/mL.

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Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

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ASJC Scopus subject areas

UN SDG

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