Non-universal decoding of the leucine codon CUG in several Candida species

Takeshi Ohama, Tsutomu Suzuki, Miki Mori, Syozo Osawa, Takuya Ueda*, Kimitsuna Watanabe, Takashi Nakase


研究成果: Article査読

146 被引用数 (Scopus)


It has been reported that CUG, a universal leucine codon, is read as serine In an asporogenlc yeast, Candida cyllndracea. The distribution of this non-universal genetic code in various yeast species was studied using an In vitro translation assay system with a synthetic messenger RNA containing CUG codons in-frame. It was found that CUG is used as a serine codon in six out of the fourteen species examined, while it is used for leucine in the remaining eight. The tRNA species responsible for the translation of codon CUG as serine was detected in all the six species in which CUG is translated as serine. The grouping according to the CUG codon assignments in these yeast species shows a good correlation with physiological classification by the chain lengths of the Isoprenold moiety of ublquinone and the cell-wall sugar contained in the yeasts. The six Candida species examined in which CUG is used as serine belong to one distinct group in Hemlascomycetes.

ジャーナルNucleic acids research
出版ステータスPublished - 1993 8月 25

ASJC Scopus subject areas

  • 遺伝学


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