@article{ae78d532119240de9e938c2acdff22a0,
title = "Novel types of two-domain multi-copper oxidases: Possible missing links in the evolution",
abstract = "An analysis of the genome sequence database revealed novel types of two-domain multi-copper oxidases. The two-domain proteins have the conspicuous combination of blue-copper and inter-domain trinuclear copper binding residues, which is common in ceruloplasmin and ascorbate oxidase but not in nitrite reductase, and therefore are considered to retain the characteristics of the plausible ancestral form of ceruloplasmin and ascorbate oxidase. A possible evolutionary relationship of these proteins is proposed.",
keywords = "Copper binding protein, Cupredoxin, Cyanobacterium, Genome sequence, Phylogeny, Rhizobium",
author = "Kensuke Nakamura and Takeshi Kawabata and Kei Yura and Nobuhiro Go",
note = "Funding Information: We thank Dr. Gautam Basu for helpful discussions. Our research was supported by the Special Coordination Funds Promoting Science and Technology, and a Grant-in-Aid for Scientific Research on Priority Areas (C) {\textquoteleft}Genome Information Science{\textquoteright} from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.",
year = "2003",
month = oct,
day = "23",
doi = "10.1016/S0014-5793(03)01000-7",
language = "English",
volume = "553",
pages = "239--244",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "3",
}