TY - JOUR
T1 - Ontogenesis of glucose sensitivity in the rat lateral hypothalamus
T2 - a brain slice study
AU - Shibata, Shigenobu
AU - Oomura, Yutaka
AU - Kita, Hitoshi
PY - 1982/9
Y1 - 1982/9
N2 - The development of glucose-sensitive neurons in the lateral hypothalamus (LHA) brain slices was examined. In 60-100-day-old rats, 20% of LHA neurons were sensitive, that is, their firing rates decreased upon increase in the glucose concentration in the perfusate and increased upon decrease in glucose concentration. In 2-, 3- and 7-day-old rats, 16% of the neurons were glucose sensitive. Results confirm glucose-sensitivity in the LHA at a very early stage of ontogeny.
AB - The development of glucose-sensitive neurons in the lateral hypothalamus (LHA) brain slices was examined. In 60-100-day-old rats, 20% of LHA neurons were sensitive, that is, their firing rates decreased upon increase in the glucose concentration in the perfusate and increased upon decrease in glucose concentration. In 2-, 3- and 7-day-old rats, 16% of the neurons were glucose sensitive. Results confirm glucose-sensitivity in the LHA at a very early stage of ontogeny.
KW - brain slice
KW - glucose-sensitive neuron
KW - lateral hypothalamic area
KW - ontogeny
KW - rat
UR - http://www.scopus.com/inward/record.url?scp=0020184758&partnerID=8YFLogxK
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U2 - 10.1016/0165-3806(82)90120-1
DO - 10.1016/0165-3806(82)90120-1
M3 - Article
C2 - 7139339
AN - SCOPUS:0020184758
SN - 0165-3806
VL - 5
SP - 114
EP - 117
JO - Developmental Brain Research
JF - Developmental Brain Research
IS - 1
ER -