Palladium-Catalyzed Carbothiolation via Trapping of the σ-Alkyl Palladium Intermediate with RSTIPS

Yosuke Hosoya; Ikumi Kobayashi; Kota Mizoguchi; Masahisa Nakada

doi:10.1021/acs.orglett.9b03046

Palladium-Catalyzed Carbothiolation via Trapping of the σ-Alkyl Palladium Intermediate with RSTIPS

Yosuke Hosoya
, Ikumi Kobayashi
, Kota Mizoguchi
, Masahisa Nakada^*

^*この研究の対応する著者

先進理工学部

研究成果: Article › 査読

26 被引用数 (Scopus)

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A palladium-catalyzed carbothiolation via the reaction of a σ-alkyl palladium intermediate with a TIPS thioether is described. It was found that the use of Cs₂CO₃, (IPr)Pd(allyl)Cl, and a TIPS thioether was key to obtaining alkyl aryl and dialkyl sulfides in high yield through the reaction of a σ-alkyl palladium intermediate. The developed reaction is applicable to a wide range of substrates and thiols.

本文言語	English
ページ（範囲）	8280-8284
ページ数	5
ジャーナル	Organic Letters
巻	21
号	20
DOI	https://doi.org/10.1021/acs.orglett.9b03046
出版ステータス	Published - 2019 10月 18

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/acs.orglett.9b03046

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title = "Palladium-Catalyzed Carbothiolation via Trapping of the σ-Alkyl Palladium Intermediate with RSTIPS",

abstract = "A palladium-catalyzed carbothiolation via the reaction of a σ-alkyl palladium intermediate with a TIPS thioether is described. It was found that the use of Cs2CO3, (IPr)Pd(allyl)Cl, and a TIPS thioether was key to obtaining alkyl aryl and dialkyl sulfides in high yield through the reaction of a σ-alkyl palladium intermediate. The developed reaction is applicable to a wide range of substrates and thiols.",

author = "Yosuke Hosoya and Ikumi Kobayashi and Kota Mizoguchi and Masahisa Nakada",

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doi = "10.1021/acs.orglett.9b03046",

language = "English",

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T1 - Palladium-Catalyzed Carbothiolation via Trapping of the σ-Alkyl Palladium Intermediate with RSTIPS

AU - Hosoya, Yosuke

AU - Kobayashi, Ikumi

AU - Mizoguchi, Kota

AU - Nakada, Masahisa

PY - 2019/10/18

Y1 - 2019/10/18

N2 - A palladium-catalyzed carbothiolation via the reaction of a σ-alkyl palladium intermediate with a TIPS thioether is described. It was found that the use of Cs2CO3, (IPr)Pd(allyl)Cl, and a TIPS thioether was key to obtaining alkyl aryl and dialkyl sulfides in high yield through the reaction of a σ-alkyl palladium intermediate. The developed reaction is applicable to a wide range of substrates and thiols.

AB - A palladium-catalyzed carbothiolation via the reaction of a σ-alkyl palladium intermediate with a TIPS thioether is described. It was found that the use of Cs2CO3, (IPr)Pd(allyl)Cl, and a TIPS thioether was key to obtaining alkyl aryl and dialkyl sulfides in high yield through the reaction of a σ-alkyl palladium intermediate. The developed reaction is applicable to a wide range of substrates and thiols.

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UR - https://www.scopus.com/pages/publications/85073054872#tab=citedBy

U2 - 10.1021/acs.orglett.9b03046

DO - 10.1021/acs.orglett.9b03046

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AN - SCOPUS:85073054872

SN - 1523-7060

VL - 21

SP - 8280

EP - 8284

JO - Organic Letters

JF - Organic Letters

IS - 20

ER -

Palladium-Catalyzed Carbothiolation via Trapping of the σ-Alkyl Palladium Intermediate with RSTIPS

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