@article{3b62255b0530485f835b9ff01f3f188b,
title = "Pd-Catalyzed Alkenyl Thioether Synthesis from Thioesters and N-Tosylhydrazones",
abstract = "A Pd-catalyzed alkenyl thioether synthesis was achieved using thioesters and N-tosylhydrazones as starting materials. The thioester acted as an efficient {"}sulfur source{"} for catalytic C-S bond formation using N-tosylhydrazone. This method gave Z-alkenyl thioethers with high diastereoselectivity (up to 99:1 diastereomeric ratio). This transformation displayed a wide functional group tolerance and was successfully applied to the late-stage derivatization of a pharmaceutical molecule to the corresponding alkenyl thioether.",
keywords = "N-tosylhydrazone, Pd-carbene, catalytic reaction, thioester, thioether",
author = "Kota Ishitobi and Kei Muto and Junichiro Yamaguchi",
note = "Funding Information: This work was supported by JSPS KAKENHI Grant Number JP19H02726, JP18H04272 (to J.Y.), JP18H04661 (Hybrid Catalysis), and JP19K15573 (to K.M.). We thank Cassandra Lim for help the preparation of N -tosylhydrazones. The Materials Characterization Central Laboratory in Waseda University is acknowledged for HRMS measurement. Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society.",
year = "2019",
month = dec,
day = "6",
doi = "10.1021/acscatal.9b04212",
language = "English",
volume = "9",
pages = "11685--11690",
journal = "ACS Catalysis",
issn = "2155-5435",
publisher = "American Chemical Society",
number = "12",
}