@article{aa8a393b76434762ab26ecf4fd6ca5e9,
title = "Pd-Catalyzed Asymmetric Dearomative Arylation of Indoles via a Desymmetrization Strategy",
abstract = "Pd-catalyzed asymmetric dearomative arylation of C3-substituted indoles is realized via a desymmetrization strategy. A BINOL-derived chiral phosphoramidite ligand is found to be highly efficient for the stereoselective control in this reaction. This method provides a convenient synthesis of spiroindolenines bearing two stereogenic centers in good yields (up to 98%) with excellent diastereo- and enantioselectivities (up to >20:1 dr and 97% ee), which could also be applied in asymmetric dearomative arylation of the simple C3-tethered indoles.",
author = "Nie, {Yu Han} and Masaaki Komatsuda and Ping Yang and Chao Zheng and Junichiro Yamaguchi and You, {Shu Li}",
note = "Funding Information: We thank the National Key R&D Program of China (2021YFA1500100), NSFC (21821002, 22031012, 91856201), Science and Technology Commission of Shanghai Municipality (19590750400, 21520780100), JSPS KAKENHI Grant Number JP21H05213, JP21K18966, and a Waseda Research Institute for Science and Engineering Grant in Aid for Young Scientists (Early Bird) for generous financial support. Publisher Copyright: {\textcopyright} 2022 American Chemical Society. All rights reserved.",
year = "2022",
month = feb,
day = "25",
doi = "10.1021/acs.orglett.2c00129",
language = "English",
volume = "24",
pages = "1481--1485",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "7",
}