@article{7fa5bfb0ef63418e9b5969efa4d6d980,
title = "Penarolide sulfates A1 and A2, new α-glucosidase inhibitors from a marine sponge Penares sp.",
abstract = "Penarolide sulfates A1 (1) and A2 (2) have been isolated as α-glucosidase inhibitors from a marine sponge Penares sp.1 Their structures including absolute stereochemistry were determined to be unique 30- and 31-membered macrolides encompassing a proline residue and three sulfate groups by interpretation of spectral data and chemical degradation. Penarolide sulfates A1 (1) and A2 (2) inhibit α-glucosidase with IC50 values of 1.2 and 1.5 μg/mL, respectively. (C) 2000 Elsevier Science Ltd.",
keywords = "Enzyme inhibitors, Macrolides, Marine metabolites, Mass spectrometry, Sponge",
author = "Yoichi Nakao and Takashi Maki and Shigeki Matsunaga and {Van Soest}, {Rob W.M.} and Nobuhiro Fusetani",
note = "Funding Information: We are thank Ms Miho Izumikawa, Dr Keiichi Konoki, and Professor Kazuo Tachibana of the University of Tokyo for measuring CD spectra. This research was partly supported by Grants-in-Aids from the Ministry of Education, Science, Sports, and Culture of Japan and Research for the Future Program from JSPS (JSPS-RFTF96I00301).",
year = "2000",
month = nov,
day = "10",
doi = "10.1016/S0040-4020(00)00750-X",
language = "English",
volume = "56",
pages = "8977--8987",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Ltd",
number = "46",
}
