抄録
Here, we report peptide probes with either single or cyclic double stranded collagen-like sequences that spontaneously acquire collagen-hybridizing ability at physiological pH. These peptides have ester bonds derived from O-acyl isopeptide units that are converted to amide bonds via intramolecular O-to-N acyl migration by a pH shift. The peptides that do not require pre-treatment for disassembly will be useful as prodrugs in theranostic treatments targeting unfolded collagen.
本文言語 | English |
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ページ(範囲) | 2823-2827 |
ページ数 | 5 |
ジャーナル | Organic and Biomolecular Chemistry |
巻 | 18 |
号 | 15 |
DOI | |
出版ステータス | Published - 2020 4月 21 |
ASJC Scopus subject areas
- 生化学
- 物理化学および理論化学
- 有機化学