TY - JOUR
T1 - Polyadenylation in mammalian mitochondria
T2 - Insights from recent studies
AU - Nagaike, Takashi
AU - Suzuki, Tsutomu
AU - Ueda, Takuya
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/4
Y1 - 2008/4
N2 - Polyadenylation in animal mitochondria is very unique. Unlike other systems, polyadenylation is needed to generate UAA stop codons that are not encoded in mitochondrial (mt) DNA. In some cases, polyadenylation is required for the mt tRNA maturation by editing of its 3′ termini. Furthermore, recent studies on human mt poly(A) polymerase (PAP) and PNPase provide new insights and questions for the regulatory mechanism and functional role of polyadenylation in human mitochondria.
AB - Polyadenylation in animal mitochondria is very unique. Unlike other systems, polyadenylation is needed to generate UAA stop codons that are not encoded in mitochondrial (mt) DNA. In some cases, polyadenylation is required for the mt tRNA maturation by editing of its 3′ termini. Furthermore, recent studies on human mt poly(A) polymerase (PAP) and PNPase provide new insights and questions for the regulatory mechanism and functional role of polyadenylation in human mitochondria.
KW - Mitochondrial
KW - Poly(A) polymerase
KW - Polyadenylation
KW - mRNA stability
UR - http://www.scopus.com/inward/record.url?scp=41549094036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41549094036&partnerID=8YFLogxK
U2 - 10.1016/j.bbagrm.2008.02.001
DO - 10.1016/j.bbagrm.2008.02.001
M3 - Review article
C2 - 18312863
AN - SCOPUS:41549094036
SN - 1874-9399
VL - 1779
SP - 266
EP - 269
JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
IS - 4
ER -