@article{3f729b2031744a688ebf5739af784b79,
title = "Potassium-regulated immobilization of cortisol aptamer for field-effect transistor biosensor to detect changes in charge distribution with aptamer transformation",
abstract = "Salivary cortisol concentration and its circadian variation were detected by optimizing the ionic concentration of a solution during the immobilization of aptamers on a field-effect transistor biosensor. This was achieved by modifying our previously developed technique of detecting uncharged cortisol using the transformation of negatively charged aptamers by controlling the aptamer spacing. This spacing control was achieved by synthesizing pseudo-cortisol-binding aptamers with a guaninequadruplex during the immobilization of the aptamers in a highly concentrated solution of K+.",
keywords = "Cortisol aptamer, Field-effect transistor, Guanine-quadruplex",
author = "Shigeki Kuroiwa and Hiroki Hayashi and Ryo Toyama and Naoto Kaneko and Katsunori Horii and Keishi Ohashi and Toshiyuki Momma and Tetsuya Osaka",
note = "Funding Information: This research was supported by JST A-STEP Program no. AS2525029M, JST COI Program Grant Number JPMJCE1303, and JST OPERA Program Grant Number JPMJOP1612, all from Japan Science and Technology Agency (JST), Japan. The authors would like to thank Dr. Iwao Waga of NEC Solution Innovators, Ltd. for proposing aptamer-based stress marker sensing and supporting our activities as a leader of the JST-COI and JST-A-STEP programs. We would also like to thank Professor Kazuaki Utsumi of Research Organization for Nano & Life Innovation, Waseda University, for his helpful advice on our research. Publisher Copyright: {\textcopyright} 2021 The Chemical Society of Japan.",
year = "2021",
month = may,
doi = "10.1246/cl.200876",
language = "English",
volume = "50",
pages = "892--895",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "Chemical Society of Japan",
number = "5",
}