@article{8fbacd3a2e38431f9169ee683ed8c206,
title = "Preparation of a Chiral Building Block by an Organocatalytic Asymmetric Intramolecular Michael Reaction",
abstract = "The preparation of a chiral building block, including a stereodiad consisting of two tertiary stereogenic centers, by a highly enantioselective organocatalytic intramolecular Michael reaction is described. The use of a chiral secondary-amine-bearing thiourea substituted with a para-nitrophenyl group in the presence of benzoic acid is key to preparing the chiral building block in high yield and excellent enantioselectivity. The prepared chiral building block has both aldehyde and nitro groups, allowing a variety of functional-group transformations necessary for the total synthesis of atisane-type terpenoids.",
keywords = "Michael reaction, enantioselectivity, intramolecular cyclization, nitroalkene, organocatalysis",
author = "Yusuke Sato and Yosuke Hosoya and Ikumi Kobayashi and Kyohei Adachi and Masahisa Nakada",
note = "Funding Information: This work was financially supported in part by JSPS KAKENHI Grant Number 15H05841 in Middle molecular strategy and a Waseda University Grant for Special Research Projects. We acknowledge supports of the Materials Characterization Central Laboratory, Waseda University, for characterization of new compounds. Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = jul,
doi = "10.1002/ajoc.201900178",
language = "English",
volume = "8",
pages = "1033--1036",
journal = "Asian Journal of Organic Chemistry",
issn = "2193-5807",
publisher = "Wiley - VCH Verlag GmbH & CO. KGaA",
number = "7",
}