Preparation of nanocarriers containing SOD mimics and their anticancer mechanism

Miho Tamai; Ryouta Araki; Kazue Hiraka; Shoichiro Asayama; Shoji Nagaoka; Tomomi Hatsugai; Akihiko Ogata; Kenichi Oyaizu; Makoto Yuasa; Hiroyoshi Kawakami

Preparation of nanocarriers containing SOD mimics and their anticancer mechanism

Miho Tamai^*, Ryouta Araki, Kazue Hiraka, Shoichiro Asayama, Shoji Nagaoka, Tomomi Hatsugai, Akihiko Ogata, Kenichi Oyaizu, Makoto Yuasa, Hiroyoshi Kawakami

^*この研究の対応する著者

研究成果: Paper › 査読

抄録

We have reported the anticancers effect by metalloporphyrins as SOD mimics on the cancer cells. Metalloporphyrins as SOD mimics convert intracellular O₂^- · to H₂O₂ and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally H ₂O₂ and OH- generated by the metalloporphyrin are expected to cause cell death. We have prepared novel liposomes containing metallporphyrins showing SOD activity. The liposomes were composed of DMPC and their size was less than 100nm. The liposomes showed a significant cytotoxicty for cancer cells when compared with cisplatin and metalloporphyrins.

本文言語	English
ページ数	1
出版ステータス	Published - 2005 12月 1
外部発表	はい
イベント	54th SPSJ Annual Meeting 2005 - Yokohama, Japan 継続期間: 2005 5月 25 → 2005 5月 27

Conference

Conference	54th SPSJ Annual Meeting 2005
国/地域	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

ASJC Scopus subject areas

工学（全般）

UN SDG

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title = "Preparation of nanocarriers containing SOD mimics and their anticancer mechanism",

abstract = "We have reported the anticancers effect by metalloporphyrins as SOD mimics on the cancer cells. Metalloporphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally H 2O2 and OH- generated by the metalloporphyrin are expected to cause cell death. We have prepared novel liposomes containing metallporphyrins showing SOD activity. The liposomes were composed of DMPC and their size was less than 100nm. The liposomes showed a significant cytotoxicty for cancer cells when compared with cisplatin and metalloporphyrins.",

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T1 - Preparation of nanocarriers containing SOD mimics and their anticancer mechanism

AU - Tamai, Miho

AU - Araki, Ryouta

AU - Hiraka, Kazue

AU - Asayama, Shoichiro

AU - Nagaoka, Shoji

AU - Hatsugai, Tomomi

AU - Ogata, Akihiko

AU - Oyaizu, Kenichi

AU - Yuasa, Makoto

AU - Kawakami, Hiroyoshi

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We have reported the anticancers effect by metalloporphyrins as SOD mimics on the cancer cells. Metalloporphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally H 2O2 and OH- generated by the metalloporphyrin are expected to cause cell death. We have prepared novel liposomes containing metallporphyrins showing SOD activity. The liposomes were composed of DMPC and their size was less than 100nm. The liposomes showed a significant cytotoxicty for cancer cells when compared with cisplatin and metalloporphyrins.

AB - We have reported the anticancers effect by metalloporphyrins as SOD mimics on the cancer cells. Metalloporphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally H 2O2 and OH- generated by the metalloporphyrin are expected to cause cell death. We have prepared novel liposomes containing metallporphyrins showing SOD activity. The liposomes were composed of DMPC and their size was less than 100nm. The liposomes showed a significant cytotoxicty for cancer cells when compared with cisplatin and metalloporphyrins.

KW - Anticancer drug

KW - Drug delivery system

KW - Liposome

KW - Metalloporphyrin

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M3 - Paper

AN - SCOPUS:33645633922

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Preparation of nanocarriers containing SOD mimics and their anticancer mechanism

抄録

Conference

ASJC Scopus subject areas

UN SDG

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