Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes

Toshinori Fujie; Yousuke Okamura; Shinji Takeoka; Makoto Handa; Yasuo Ikeda

Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes

Toshinori Fujie^*, Yousuke Okamura, Shinji Takeoka, Makoto Handa, Yasuo Ikeda

^*この研究の対応する著者

先進理工学部

研究成果: Paper › 査読

抄録

We conjugated dodecapeptide (H12), which was a part of the amino acid sequence of fibrinogen, to the terminal of polyethyleneglycol (PEG) chains of the PEG-modified polymerized albumin particles(polyAlb), and confirmed that they showed a significant hemostatic effect even 3hrs after injection(40mg/kg) in thrombocytopenic rats.

本文言語	English
ページ数	1
出版ステータス	Published - 2006 10月 19
イベント	55th SPSJ Annual Meeting - Nagoya, Japan 継続期間: 2006 5月 24 → 2006 5月 26

Conference

Conference	55th SPSJ Annual Meeting
国/地域	Japan
City	Nagoya
Period	06/5/24 → 06/5/26

ASJC Scopus subject areas

工学（全般）

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「Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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abstract = "We conjugated dodecapeptide (H12), which was a part of the amino acid sequence of fibrinogen, to the terminal of polyethyleneglycol (PEG) chains of the PEG-modified polymerized albumin particles(polyAlb), and confirmed that they showed a significant hemostatic effect even 3hrs after injection(40mg/kg) in thrombocytopenic rats.",

keywords = "Blood circulation clearance, Fibrinogen γ chain dodecapeptide (H12), Hemostatic effect, Platelet substitutes, Polyethyleneglycol",

author = "Toshinori Fujie and Yousuke Okamura and Shinji Takeoka and Makoto Handa and Yasuo Ikeda",

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T1 - Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes

AU - Fujie, Toshinori

AU - Okamura, Yousuke

AU - Takeoka, Shinji

AU - Handa, Makoto

AU - Ikeda, Yasuo

PY - 2006/10/19

Y1 - 2006/10/19

N2 - We conjugated dodecapeptide (H12), which was a part of the amino acid sequence of fibrinogen, to the terminal of polyethyleneglycol (PEG) chains of the PEG-modified polymerized albumin particles(polyAlb), and confirmed that they showed a significant hemostatic effect even 3hrs after injection(40mg/kg) in thrombocytopenic rats.

AB - We conjugated dodecapeptide (H12), which was a part of the amino acid sequence of fibrinogen, to the terminal of polyethyleneglycol (PEG) chains of the PEG-modified polymerized albumin particles(polyAlb), and confirmed that they showed a significant hemostatic effect even 3hrs after injection(40mg/kg) in thrombocytopenic rats.

KW - Blood circulation clearance

KW - Fibrinogen γ chain dodecapeptide (H12)

KW - Hemostatic effect

KW - Platelet substitutes

KW - Polyethyleneglycol

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T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

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