Prostaglandin F metabolite levels in plasma, amniotic fluid, and urine during pregnancy and labor

Kazuo Satoh*, Takehiko Yasumizu, Hideoki Fukuoka, Katsuyuki Kinoshita, Yoshiharu Kaneko, Mitose Tsuchiya, Shoichi Sakamoto


研究成果: Article査読

55 被引用数 (Scopus)


Levels of 13, 14-dihydro 15-keto-prostaglandin F (dhk PGF) in the plasma of 30 patients as well as in the amniotic fluid of 17 patients, and 5α, 7α-dihydroxy 11-keto tetranor-prostane 1,16-dioic acid (the main urinary metabolite of PGF [PGF MUM]) levels in the urine of 30 patients were measured by radioimmunoassay during pregnancy, labor, and the puerperium. During pregnancy, no increase in dhk PGF (ng/ml) in plasma was detected as the time of delivery approached. The levels of dhk PGF during the second stage (0.64 ± 0.15) and also at delivery (0.88 ± 0.27) were significantly elevated over those in the first stage (0.38 ± 0.29) (P <0.025 and P < 0.005, respectively). Its level 2 hours after delivery was reduced to predelivery levels. Its levels in umbilical arterial and venous blood were 0.71 ± 0.26 and 0.67 ± 0.26, respectively. A significant elevation (P < 0.01) of dhk PGF from 0.89 ± 0.21 before labor to 6.16 ± 2.40 at delivery was found in amniotic fluid. The hourly excretion of PGF MUM (μg/hour) increased significantly from pregnancy levels to 1.06 ± 0.45 in the first stage (P < 0.01), to 7.67 ± 4.31 (P < 0.005) for the first 2 hours after delivery, and 2.37 ± 1.08 from 2 to 12 hours after delivery (P < 0.01). The excretion of PGF MUM decreased to pregnancy levels 12 hours post partum. These data indicate that during labor the production of PGF is remarkably increased.

ジャーナルAmerican Journal of Obstetrics and Gynecology
出版ステータスPublished - 1979 4月 15

ASJC Scopus subject areas

  • 医学(全般)
  • 産婦人科学


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