Pulmonary effects of sodium fluoride aerosol on rats

X. Q. Chen*, K. Machida, K. Isizaki, N. Nisio, M. Ando

*この研究の対応する著者

    研究成果: Article査読

    7 被引用数 (Scopus)

    抄録

    Five-week-old male Fischer rats were exposed 3 hr per day for either 5 or 10 days to three concentrations of sodium fluoride aerosol (1.11, 3.33, and 10.3 mg F/m3). A significant increase in lung weight was observed at the highest concentration. The activity of lactate dehydrogenase (LDH) and total protein concentration in bronchoalveolar lavage (BAL) fluid were also significantly higher in rats exposed to 3.33 and 10.3 mg F/m3. Neutrophil phagocytic activity in the blood was stimulated by 10-day exposure, and a significant increase in bactericidal activity and superoxide production was observed by exposure to 3.33 mg F/m3 but not to 10.3 mg F/m3.

    本文言語English
    ページ(範囲)159-167
    ページ数9
    ジャーナルFluoride
    33
    4
    出版ステータスPublished - 2000

    ASJC Scopus subject areas

    • 農業および生物科学(全般)
    • 農業および生物科学(その他)
    • 健康、毒物学および変異誘発
    • 公衆衛生学、環境および労働衛生
    • 毒物学

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