@article{803ff3dc2c704fa8b05433a0d819d52f,
title = "Rab family small GTPases-mediated regulation of intracellular logistics in neural development",
abstract = "Rab family small GTPases play essential roles in various cellular events via the regulation of intracellular logistics comprising a large number of membrane traffic pathways. Emerging evidence reveals the physiological roles of Rab proteins in several tissues, including developing brains. Many Rab proteins, such as Rab5, Rab6, Rab7, Rab8, Rab10, Rab11, Rab17 and Rab18, are shown to regulate neurite outgrowth in PC12 cells and/or axon and dendrite formation in primary cultured neurons. Recent studies have also revealed in vivo roles of several Rab family small GTPases in brain development and its related neurological disorders. In this review, we introduce the physiological function of Rab family proteins in neural development with particular focus on neurite outgrowth and neuronal migration.",
keywords = "Brain development, CdK5, Endocytosis, JNK, Membrane traffic, Neurite outgrowth, Neuronal migration, Rab10, Rab11, Rab17, Rab18, Rab5, Rab6, Rab7, Rab8",
author = "Mima Shikanai and Michisuke Yuzaki and Takeshi Kawauchi",
note = "Funding Information: Acknowledgements. The authors thank Dr. Ruth T. Yu for English proofreading of the manuscript. The authors{\textquoteright} research group is funded by JSPS KAKENHI Grant Numbers JP26290015 (to T.K.) and Grant-in Scientific Research on Innovation Areas “Dynamic regulation of Brain Function by Scrap & Build System” (JP17H05757 to T.K., JP16H06461 to M.Y.) from Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT), AMED under Grant number JP17GM5010002 (to T.K.), and Takeda Science Foundation (to T.K.). Publisher Copyright: {\textcopyright} 2018, Histology and Histopathology. All rights reserved.",
year = "2018",
month = aug,
doi = "10.14670/HH-11-956",
language = "English",
volume = "33",
pages = "765--771",
journal = "Histology and Histopathology",
issn = "0213-3911",
publisher = "Histology and Histopathology",
number = "8",
}