Reduction of serum TARC levels in atopic dermatitis by topical anti-inflammatory treatments

Yumi Yasukochi*, Takeshi Nakahara, Takeru Abe, Makiko Kido-Nakahara, Futoshi Kohda, Satoshi Takeuchi, Akihito Hagihara, Masutaka Furue


    研究成果: Article査読

    16 被引用数 (Scopus)


    Background: Serum thymus and activation-regulated chemokine (TARC) levels are associated with the disease activity of patients with atopic dermatitis (AD) and sensitively reflect short-term changes in skin conditions. The main treatment for AD is topical agent application.

    Objective: This study investigated the relationship between serum TARC levels and the dosage of topical agents, including corticosteroids and/or tacrolimus, in patients with AD.

    Methods: The serum TARC levels of 56 AD patients and the amounts of topical agents prescribed to them were investigated retrospectively. The weekly reduction in serum TARC levels and weekly dosage of topical agents among AD patients were compared and their associations were evaluated.

    Results: The dosage of topical agents was closely related to serum TARC levels. One gram of strong rank steroid or the equivalent amount of steroid/tacrolimus is required to reduce serum TARC levels by 9.94 pg/mL weekly in moderate to severe AD patients. Higher initial TARC levels require more topical agent, which results in a more rapid decrease in TARC levels. The serum TARC levels and eosinophil numbers in peripheral blood are significantly correlated.

    Conclusion: Serum TARC level improvement and topical agent dosage are strongly correlated. TARC and eosinophil numbers are significantly correlated, but the wider range of TARC levels seems to be clinically more useful for monitoring AD severity. The serum TARC level is a very sensitive biomarker for monitoring the severity and treatment response in AD.

    ジャーナルAsian Pacific Journal of Allergy and Immunology
    出版ステータスPublished - 2014 9月 1

    ASJC Scopus subject areas

    • 免疫アレルギー学
    • 免疫学
    • 医学(全般)


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