Relation between VE/VCO2 slope and maximum phonation time in chronic heart failure patients

Kazuhiro P. Izawa*, Satoshi Watanabe, Peter H. Brubaker, Shinobu Tochimoto, Yasuyuki Hirano, Shinya Matsushima, Tomohiro Suzuki, Koichiro Oka, Takashi Saito, Yutaka Omori, Kengo Suzuki, Naohiko Osada, Kazuto Omiya, Hiroyuki Shimizu, Yoshihiro J. Akashi


研究成果: Article査読

4 被引用数 (Scopus)


This study aimed to determine the relation between the regression slope relating minute ventilation to carbon dioxide output (VE/VCO2 slope) and maximum phonation time (MPT), and the MPT required to attain a threshold value for VE/VCO2 slope of ≤34 in chronic heart failure (CHF) patients. This cross-sectional study enrolled 115 CHF patients (mean age, 54.5 years; men, 84.9%). VE/VCO2 slope was assessed during cardiopulmonary exercise testing (CPX). Thereafter, patients were divided into 2 groups according to exercise capacity: VE/VCO2 slope ≤34 (VE/VCO2 ≤34 group, n = 81) and VE/VCO2 slope >34 (VE/VCO2 >34 group, n = 34). For MPT measurements, all patients produced a sustained vowel/a:/ for as long as possible during respiratory effort from the seated position. All subjects showed significant negative correlation between VE/VCO2 slope and MPT (r = -0.51, P < 0.001). After adjustment for clinical characteristics, MPT was significantly higher in the VE/VCO2 ≤34 group vs VE/VCO2 >34 group (21.4 ± 6.4 vs 17.4 ± 4.3 s, F = 7.4, P = 0.007). The appropriate MPT cut-off value for identifying a VE/VCO2 slope ≤34 was 18.12 seconds. An MPT value of 18.12 seconds may be a useful target value for identifying CHF patients with a VE/VCO2 slope ≤34 and for risk management in these patients.

ジャーナルMedicine (United States)
出版ステータスPublished - 2014 12月 13

ASJC Scopus subject areas

  • 医学(全般)


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