Relationship between the harmonic components and illuminating frequency for the microbubbles: Experimental and numerical consideration

The nonlinear response of microbubbles has been considered as a basis for ultrasound blood vascular image enhancement system using nonlinear behavior of microbubbles. In this paper, the relationship between the condition of microbubble samples and illuminating conditions of ultrasound for the microbubbles coated with a surfactant membrane are studied experimentally and by numerical simulation. The effect of the number of ultrasound pulse shots, illuminating frequency and size distribution of bubbles are considered, experimentally. To simulate the relationship between the illuminating frequency of ultrasound exposed to the bubbles and the behavior of the harmonic component, a mathematical model, taking into consideration the compressibility of the surrounding liquid around the bubbles and the effect of the coated membrane is proposed.